Mouse Monoclonal EphB2 Antibody

The EphB2 antibody is a crucial tool in studying the EphB2 receptor, a member of the Eph receptor tyrosine kinase family, which plays pivotal roles in cell-cell communication, tissue patterning, and developmental processes. EphB2 interacts with membrane-bound ephrin-B ligands to mediate bidirectional signaling, influencing cell adhesion, migration, and boundary formation. It is particularly significant in nervous system development, synaptic plasticity, and angiogenesis. Dysregulation of EphB2 signaling has been implicated in various pathologies, including cancer (e.g., colorectal, breast), neurological disorders, and cardiovascular diseases. In cancer, EphB2 exhibits context-dependent roles, acting as either a tumor suppressor or promoter depending on cellular context and disease stage. Researchers employ EphB2 antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and activation status. These antibodies help elucidate EphB2's interaction networks, downstream pathways (e.g., MAPK, PI3K), and its crosstalk with other signaling molecules. Recent studies also explore EphB2's potential as a therapeutic target, particularly in drug-resistant cancers. Validation of EphB2 antibodies remains essential, given the structural complexity of Eph receptors and overlapping epitopes within the family.