Mouse Monoclonal EhpB6 Antibody

The EhpB6 antibody is a monoclonal antibody primarily associated with research targeting the Eph receptor family, specifically the EphB6 receptor. Eph receptors, the largest subgroup of receptor tyrosine kinases (RTKs), play critical roles in cell-cell communication, tissue patterning, and developmental processes. EphB6 is unique among Eph receptors as it lacks intrinsic kinase activity, relying instead on interactions with other signaling molecules to mediate cellular responses. It has been implicated in diverse physiological and pathological contexts, including cancer progression, immune regulation, and neuronal development. Studies suggest EphB6 exhibits dual roles in malignancies—acting as both a tumor suppressor (e.g., inhibiting metastasis in colorectal cancer) and a promoter (e.g., enhancing survival in T-cell leukemia). The EhpB6 antibody is widely used in immunohistochemistry, flow cytometry, and Western blotting to detect EphB6 expression levels in tissues or cell lines, aiding in mechanistic studies of its signaling pathways. Recent research also explores its potential therapeutic applications, particularly in modulating EphB6-related pathways to influence tumor microenvironments or immune cell activity. However, functional complexities of EphB6. including ligand-binding dynamics and crosstalk with other receptors, remain active areas of investigation.