| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CIB; KIP; KIP1; SIP2-28 |
| Entrez GeneID | 10519 |
| clone | 5A1F5E12 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of CIB1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CIB1抗体相关的文献示例(注：文献为虚拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *"CIB1 modulates apoptosis in breast cancer cells through calcium-dependent signaling pathways"*
**作者**: Smith A, et al.
**摘要**: 本研究利用CIB1特异性抗体进行免疫沉淀和Western blot分析，揭示了CIB1通过调控细胞内钙离子信号通路影响乳腺癌细胞凋亡的分子机制，为靶向CIB1的癌症治疗提供依据。
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2. **文献名称**: *"Interaction of CIB1 with integrin αIIbβ3 in platelet activation"*
**作者**: Zhang L, et al.
**摘要**: 通过免疫荧光和共聚焦显微镜技术结合CIB1抗体，研究发现CIB1与整合素αIIbβ3的相互作用在血小板活化中起关键作用，为血栓性疾病研究提供了新靶点。
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3. **文献名称**: *"CIB1 as a novel biomarker for glioblastoma progression"*
**作者**: Chen H, et al.
**摘要**: 采用CIB1抗体进行组织芯片(TMA)分析，发现CIB1在胶质母细胞瘤中高表达且与患者预后显著相关，提示其可作为潜在诊断标志物。
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如需实际文献，建议检索PubMed、Web of Science等平台，关键词：**CIB1 antibody** + **application**(实验方向如cancer, signaling等)。
**Background of CIB1 Antibody**
The CIB1 (Calcium and Integrin Binding protein 1) antibody is a tool used to detect and study the CIB1 protein, a 22 kDa ubiquitously expressed protein involved in diverse cellular processes. CIB1. also known as kinase-interacting protein 2 (KIP2), contains four calcium-binding EF-hand motifs, enabling it to interact with calcium-dependent signaling pathways. It binds integrin αIIbβ3 in platelets, regulating cell adhesion and migration, and interacts with multiple partners, including PAK1. DNA-PK, and presenilin-2. implicating roles in cell cycle regulation, DNA repair, and apoptosis.
CIB1 antibodies are critical for investigating its dual roles in cancer progression (e.g., promoting tumor growth or metastasis) and neuroprotection (e.g., modulating neuronal survival pathways). These antibodies, often monoclonal or polyclonal, are validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. Challenges in CIB1 research include its dynamic subcellular redistribution and post-translational modifications, necessitating high-specificity antibodies. Reliable CIB1 antibodies thus support advancing studies in cancer biology, cardiovascular diseases, and neurodegenerative disorders.
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