| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MGC10442 |
| Entrez GeneID | 640 |
| clone | 9D10B7 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of BLK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于BLK抗体的3篇参考文献摘要(文献及内容为模拟示例，非真实存在)：
1. **文献名称**：*"BLK genetic variant promotes autoimmunity through B cell hyperactivation in systemic lupus erythematosus"*
**作者**：Hom G. et al. (2008)
**摘要**：通过全基因组关联研究(GWAS)发现BLK基因座与系统性红斑狼疮(SLE)显著相关，BLK蛋白通过调控B细胞受体信号通路异常激活，导致自身抗体产生。
2. **文献名称**：*"The role of BLK in B cell development and tolerance"*
**作者**：Cornall R.J. et al. (2012)
**摘要**：综述BLK在B细胞成熟中的关键作用，实验表明BLK缺陷小鼠表现出B细胞分化异常，提示其通过调节抗原信号维持免疫耐受。
3. **文献名称**：*"Targeting BLK tyrosine kinase in autoimmune disorders: Preclinical evidence from a rheumatoid arthritis model"*
**作者**：Thome M. et al. (2016)
**摘要**：在小鼠类风湿性关节炎模型中，BLK特异性抑制剂可减少炎症因子分泌，证实BLK作为潜在治疗靶点的可行性。
4. **文献名称**：*"BLK polymorphisms modulate anti-DNA antibody production in lupus patients"*
**作者**：Deng Y., Tsao B.P. (2010)
**摘要**：分析BLK基因多态性如何通过影响B细胞信号传导通路，导致SLE患者抗双链DNA抗体水平升高。
(注：以上文献为虚构示例，实际引用需核实真实数据库。)
BLK (B-lymphoid kinase) is a member of the Src family of tyrosine kinases, primarily expressed in B cells and involved in B-cell receptor (BCR) signaling. It plays a critical role in B-cell development, differentiation, and activation by regulating downstream pathways like MAPK and NF-κB. Dysregulation of BLK has been implicated in autoimmune diseases, particularly systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genome-wide association studies (GWAS) identified single nucleotide polymorphisms (SNPs) in the BLK gene as susceptibility loci for these conditions, suggesting its role in modulating immune tolerance.
BLK antibodies, either autoantibodies targeting BLK or antibodies used experimentally to detect BLK protein, are of interest in both research and diagnostics. In autoimmune contexts, altered BLK expression or function may disrupt B-cell homeostasis, contributing to pathogenic autoantibody production. Anti-BLK autoantibodies have been reported in subsets of SLE patients, potentially serving as biomarkers for disease stratification.
Therapeutically, targeting BLK signaling is explored to modulate aberrant B-cell activity, though challenges remain in balancing efficacy and immune suppression. Research continues to unravel BLK's tissue-specific roles, isoform variations, and interactions with environmental triggers in autoimmunity. Its dual function as a kinase and a genetic risk factor makes BLK a compelling subject for understanding immune dysregulation and developing precision therapies.
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