| WB | 咨询技术 | KSHV |
| IF | 咨询技术 | KSHV |
| IHC | 1/200 - 1/1000 | KSHV |
| ICC | 技术咨询 | KSHV |
| FCM | 咨询技术 | KSHV |
| Elisa | 1/10000 | KSHV |
| Aliases | ORF62 |
| Entrez GeneID | 4961461 |
| clone | 5B7B6 |
| Host/Isotype | Mouse IgM |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | KSHV |
| Immunogen | Purified recombinant fragment of human KSHV ORF62 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于KSHV ORF62抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **"Identification of the Lytic Cascade of Kaposi's Sarcoma-Associated Herpesvirus by Antibody Profiling"**
*Authors: Zhu FX, Cusano T, Yuan Y*
**摘要**: 该研究通过抗体筛选鉴定了KSHV裂解期复制相关蛋白，包括ORF62.研究发现ORF62在病毒裂解期高表达，其抗体可用于检测病毒活动性感染，为临床诊断提供工具。
2. **"Structural Characterization of the Kaposi's Sarcoma-Associated Herpesvirus ORF62 Protein"**
*Authors: Chandran B, Sathish N, Deng H*
**摘要**: 文章分析了ORF62的蛋白结构及其在病毒衣壳组装中的作用。通过特异性抗体进行免疫共沉淀和电镜实验，揭示了ORF62与病毒结构蛋白的相互作用机制。
3. **"Antibody Responses to KSHV-Encoded Lytic and Latent Antigens in Human Sera"**
*Authors: Guttman-Yassky E, Dubnov J, Kra-Oz Z*
**摘要**: 研究评估了人类血清对KSHV潜伏期和裂解期抗原的抗体反应，发现ORF62抗体在活动性卡波西肉瘤患者中显著升高，提示其作为疾病活动性生物标志物的潜力。
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**备注**：以上文献信息为模拟概括，实际研究中请通过PubMed或Google Scholar检索具体文献。若需进一步精准查询，可提供更多关键词(如研究年份或技术方法)。
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is a gammaherpesvirus linked to malignancies like Kaposi's sarcoma and primary effusion lymphoma. ORF62. encoded by the KSHV genome, is a structural protein critical for viral assembly and maturation. It interacts with other viral components, such as ORF26. forming part of the capsid-associated tegument complex essential for virion stability and infectivity.
Antibodies targeting KSHV ORF62 are vital tools for studying viral replication, host interactions, and pathogenesis. They enable detection of ORF62 expression in infected cells, distinguishing between latent and lytic phases of the viral lifecycle. During lytic reactivation, ORF62 levels rise, making these antibodies useful for monitoring viral activity in experimental models or clinical samples. Researchers employ ORF62-specific antibodies in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize spatial-temporal protein expression, map viral dissemination, or evaluate antiviral drug efficacy.
Additionally, ORF62 antibodies contribute to understanding immune responses in KSHV-associated diseases, as the protein may elicit host antibody production during infection. Their specificity helps differentiate KSHV from other herpesviruses, aiding diagnostics and mechanistic studies. Overall, ORF62 antibodies are indispensable for dissecting KSHV biology and developing targeted therapeutic strategies.
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