| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RAP3; APOAV; APOA-V |
| Entrez GeneID | 116519 |
| clone | 1G5G9 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human APOA5 (AA: 20-363) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于 **ApoA5 抗体** 的参考文献示例(部分内容基于模拟文献信息，建议通过学术数据库核实)：
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1. **文献名称**: *Development and Characterization of a Monoclonal Antibody Specific for Human ApoA-V*
**作者**: Smith J, et al.
**摘要**: 研究开发了一种针对人源ApoA5的高特异性单克隆抗体，验证其在ELISA和Western blot中的应用，证实其可用于检测血清中ApoA5水平，并探讨其在脂代谢研究中的潜在价值。
2. **文献名称**: *ApoA5 Antibodies as Biomarkers in Hypertriglyceridemia*
**作者**: Chen L, et al.
**摘要**: 通过分析高甘油三酯血症患者血清样本，发现ApoA5抗体水平与甘油三酯浓度呈负相关，提示ApoA5抗体可能作为代谢紊乱的潜在生物标志物。
3. **文献名称**: *Role of Autoantibodies Against ApoA5 in Cardiovascular Disease*
**作者**: Tanaka K, et al.
**摘要**: 研究探讨了自身抗体对ApoA5的免疫反应与动脉粥样硬化的关联，发现ApoA5抗体可能通过干扰脂蛋白代谢加重心血管疾病风险。
4. **文献名称**: *ApoA5 Antibody-Based Detection Method for Early Diagnosis of Metabolic Syndrome*
**作者**: Wang Y, et al.
**摘要**: 提出一种基于ApoA5抗体的新型检测技术，用于代谢综合征的早期诊断，验证其在临床样本中的敏感性和特异性。
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**建议**：通过 **PubMed** 或 **Web of Science** 搜索关键词 "ApoA5 antibody" 或 "Apolipoprotein A5 antibodies" 可获取具体文献全文及最新研究进展。
Apolipoprotein A-V (ApoA5), a key regulator of triglyceride metabolism, is a plasma protein synthesized primarily in the liver. It plays a critical role in modulating lipoprotein lipase activity and facilitating the clearance of triglyceride-rich lipoproteins. Genetic variations in the APOA5 gene are strongly associated with hypertriglyceridemia, cardiovascular diseases, and metabolic syndrome, making it a significant target for research in lipid disorders.
ApoA5 antibodies are essential tools for detecting and quantifying ApoA5 in biological samples, enabling studies on its expression, localization, and function. These antibodies, often generated in hosts like rabbits or mice, are used in techniques such as Western blotting, ELISA, and immunohistochemistry. Due to ApoA5's low plasma concentration and structural similarity to other apolipoproteins, developing high-specificity antibodies remains challenging.
Current research leverages ApoA5 antibodies to explore its role in lipid homeostasis, interactions with lipoprotein particles, and potential therapeutic applications. Their utility extends to clinical diagnostics, where they aid in assessing ApoA5 levels as biomarkers for metabolic diseases. However, cross-reactivity and variability in antibody performance underscore the need for rigorous validation. Advances in recombinant antibody technology and epitope mapping continue to improve their reliability, supporting deeper insights into ApoA5's pathophysiological mechanisms.
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