| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLAP; Me10; CIPER; c-E10; CARMEN |
| Entrez GeneID | 8915 |
| clone | 4F8 |
| WB Predicted band size | 26kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human BCL-10 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于BCL-10抗体的3篇代表性文献(模拟示例，非真实文献)：
1. **"BCL-10 expression in MALT lymphoma: a diagnostic marker and role in NF-κB activation"**
- **作者**: Uno et al.
- **摘要**: 研究BCL-10蛋白在黏膜相关淋巴组织(MALT)淋巴瘤中的异常表达，揭示其作为诊断标志物的潜力，并证明其通过激活NF-κB信号通路促进肿瘤发生。
2. **"Structural characterization of BCL-10 and its caspase recruitment domain (CARD)"**
- **作者**: Zhang et al.
- **摘要**: 解析BCL-10蛋白的CARD结构域三维结构，阐明其通过寡聚化与CARD9/CARD11相互作用，调控下游炎症及凋亡信号通路的分子机制。
3. **"BCL-10 antibody application in immunohistochemical diagnosis of lymphoid malignancies"**
- **作者**: Chen et al.
- **摘要**: 评估BCL-10抗体在免疫组织化学中的应用，证实其在区分MALT淋巴瘤与其他B细胞淋巴瘤亚型中的高特异性及临床实用性。
(注：以上文献为示例，实际引用请通过PubMed或学术数据库检索真实研究。)
BCL-10 (B-cell lymphoma 10) is a cytosolic adaptor protein involved in regulating immune responses, apoptosis, and NF-κB signaling pathways. It contains a caspase recruitment domain (CARD) that mediates interactions with other CARD-containing proteins, such as MALT1 and CARD11. forming complexes critical for antigen receptor-mediated NF-κB activation. Dysregulation of BCL-10 is linked to immune disorders and malignancies, particularly mucosa-associated lymphoid tissue (MALT) lymphomas, where chromosomal translocations (e.g., t(1;14)) lead to its overexpression.
BCL-10 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. In research, these antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect BCL-10 in tissues or cell lines. Clinically, they aid in diagnosing lymphomas by identifying aberrant BCL-10 expression patterns. Studies also utilize BCL-10 antibodies to explore its role in inflammation, autoimmunity, and cancer progression, offering insights into therapeutic targets.
Despite its pro-apoptotic name, BCL-10 primarily functions as a signaling activator, contrasting with other BCL family members. Its dual role in promoting survival or apoptosis, depending on cellular context, underscores its biological complexity. Antibodies against BCL-10 thus remain vital for unraveling its multifaceted contributions to immunity and disease.
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