关键信息
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基因名
NKG2C/CD159c
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简介
The NKG2C/CD159c protein is an immune-activating receptor that critically differentiates self from non-self by forming a complex with KLRD1. It recognizes non-canonical MHC-E loaded with signal sequence-derived peptides from MHC-G molecules and contributes to the generation and effector function of adaptive NK cells, playing a role in maternal-fetal tolerance. NKG2C/CD159c Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived NKG2C/CD159c protein, expressed by HEK293 , with C-hFc labeled tag.
- 应用
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别名
CD159c; KLRC2; NKG2C; NK cell receptor C
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9MZK6
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表达区间
I94-L231
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蛋白长度
Extracellular Domain
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分子量
52-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NKG2C (also known as CD159c) is an activating receptor predominantly found on natural killer (NK) cells and certain subsets of T cells. It plays a crucial role in the immune response against tumor cells and viral infections. Research has increasingly focused on NKG2C due to its potential implications in immunotherapy, given its ability to enhance the cytotoxic activity of NK cells. Unlike its counterpart NKG2A, which is inhibitory, NKG2C can trigger powerful anti-tumor responses, making it a promising target for enhancing immune reactions. The variable expression of NKG2C in different populations, influenced by genetic and environmental factors, adds another layer of complexity to its study. Recombinant NKG2C protein has been developed to facilitate investigations into its functional properties, receptor-ligand interactions, and signaling pathways involved in NK cell activation. This research is pivotal as it could lead to advances in therapeutic strategies for cancer and viral diseases, promoting tumor recognition and eradication. Overall, NKG2C/CD159c remains an important focus in the fields of immunology and translational medicine, with significant potential to inform future immunotherapeutic approaches.
