关键信息
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基因名
CD158d/KIR2DL4
- 应用
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别名
rHuCD158d, His; Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; KIR103AS
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
ADY38409.1
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表达区间
W22-H242
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氨基酸序列
WAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRTGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDASDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLH
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蛋白长度
Partial
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分子量
30-40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD158d, also known as KIR2DL4, is a member of the killer immunoglobulin-like receptor (KIR) family, which plays a critical role in the regulation of immune responses, particularly in natural killer (NK) cells. KIR2DL4 is unique among KIRs due to its ability to recognize non-peptide ligands, specifically HLA-G, a major histocompatibility complex (MHC) class I molecule implicated in immune tolerance during pregnancy and in tumor escape mechanisms. The interaction between KIR2DL4 and HLA-G is believed to modulate NK cell activity, influencing both immunological tolerance and the immune response to tumors and infections. Research on CD158d/KIR2DL4 recombinant proteins has emerged to better understand the structural and functional aspects of this receptor-ligand interaction. Such studies aim to elucidate how KIR2DL4 contributes to immune regulation and the potential for therapeutic interventions in conditions characterized by immune dysregulation, such as cancer, pregnancy complications, and autoimmune diseases. With advancements in recombinant protein technology, scientists can produce and characterize CD158d/KIR2DL4 proteins, enabling detailed binding studies and functional assays. This research not only enhances our understanding of NK cell biology but also paves the way for the development of novel immunotherapies that harness or inhibit the KIR2DL4-HLA-G pathway in clinical settings.
