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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BMP8A |
| Uniprot No | Q7Z5Y6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 264-402aa |
| 氨基酸序列 | AVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMKPN AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于BMP8A重组蛋白的模拟参考文献示例(实际文献需通过学术数据库验证)：
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1. **标题**: *"Recombinant BMP8A Promotes Osteogenic Differentiation in Human Mesenchymal Stem Cells"*
**作者**: Smith J, et al.
**摘要**: 研究团队通过大肠杆菌系统成功表达并纯化了重组BMP8A蛋白。实验表明，该蛋白可显著增强人间充质干细胞的成骨分化能力，提示其在骨组织工程中的潜在应用价值。
2. **标题**: *"BMP8A Regulates Thermogenic Activation in Adipose Tissues via a SMAD-Dependent Pathway"*
**作者**: Zhang Y, et al.
**摘要**: 通过注射重组BMP8A蛋白至小鼠模型，研究发现其能激活褐色脂肪组织的产热功能，并改善高脂饮食诱导的代谢紊乱，揭示了BMP8A在能量代谢调控中的作用机制。
3. **标题**: *"Recombinant BMP8A Enhances Spermatogonial Stem Cell Maintenance In Vitro"*
**作者**: Jones R, et al.
**摘要**: 利用重组BMP8A蛋白处理小鼠精原干细胞，发现其通过激活ALK2受体维持干细胞自我更新，为男性不育症的体外治疗提供了新思路。
4. **标题**: *"BMP8A Signaling in Cancer: Dual Activation of SMAD and MAPK Pathways"*
**作者**: Lee S, et al.
**摘要**: 研究显示，重组BMP8A蛋白通过同时激活SMAD和MAPK信号通路，促进特定癌细胞的迁移能力，提示其可能成为肿瘤治疗的靶点。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed、Web of Science等平台检索确认。BMP8A的研究相对较少，可扩展搜索关键词(如BMP8A + recombinant/function/signaling)或关联家族蛋白(如BMP7/BMP8B)以获取更多信息。
**Background of BMP8A Recombinant Protein**
Bone Morphogenetic Protein 8A (BMP8A) is a member of the BMP family, which belongs to the transforming growth factor-beta (TGF-β) superfamily. BMPs are multifunctional signaling molecules critical in regulating cellular processes such as proliferation, differentiation, apoptosis, and tissue development. BMP8A, specifically, plays roles in embryonic development, particularly in skeletal formation, neurogenesis, and organogenesis. Emerging studies also highlight its involvement in adult tissue homeostasis, including metabolic regulation and reproductive functions.
Recombinant BMP8A protein is produced using biotechnological methods, often through expression systems like *E. coli* or mammalian cell cultures, followed by purification to ensure high specificity and biological activity. This engineered protein retains the functional properties of native BMP8A, enabling researchers to study its mechanisms in vitro and in vivo. Its applications span basic research—such as elucidating signaling pathways (e.g., SMAD-dependent and non-canonical pathways)—and translational studies, including drug development and regenerative medicine. For instance, BMP8A has been explored for its potential in bone repair, adipocyte regulation, and fertility-related therapies.
Despite its significance, BMP8A remains less characterized compared to other BMPs (e.g., BMP2 or BMP7). Current research focuses on clarifying its tissue-specific roles, interaction with receptors (e.g., BMPR-I/II), and crosstalk with other signaling networks. The availability of recombinant BMP8A accelerates these investigations, offering tools for structural analysis, antibody production, and therapeutic candidate screening. Challenges include optimizing its stability and delivery in clinical settings, underscoring the need for continued interdisciplinary research.
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