| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF606 |
| Uniprot No | Q8WXB4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-792 aa |
| 活性数据 | MAAINPWASWGALTDQSWGMTAVDPWASWALCPQYPAWHVEGSLEEGRRATGLPAAQVQEPVTFKDVAVDFTQEEWGQLDLVQRTLYRDVMLETYGHLLSVGNQIAKPEVISLLEQGEEPWSVEQACPQRTCPEWVRNLESKALIPAQSIFEEEQSHGMKLERYIWDDPWFSRLEVLGCKDQLEMYHMNQSTAMRQMVFMQKQVLSQRSSEFCGLGAEFSQNLNFVPSQRVSQIEHFYKPDTHAQSWRCDSAIMYADKVTCENNDYDKTVYQSIQPIYPARIQTGDNLFKCTDAVKSFNHIIHFGDHKGIHTGEKLYEYKECHQIFNQSPSFNEHPRLHVGENQYNYKEYENIFYFSSFMEHQKIGTVEKAYKYNEWEKVFGYDSFLTQHTSTYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYECDKCGKVFRNRSALTKHERTHTGIKPYECNKCGKAFSWNSHLIVHKRIHTGEKPYVCNECGKSFNWNSHLIGHQRTHTGEKPFECTECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAKPYKCTECGKSFSWSSHLIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIHSGIKPYECNKCGKSCSQMAHLVRHQRTHTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKCNQCERSFNCSSHLIAHRRTHTGEKPYRCNECGKAFNESSSLIVHLRNHTGEKPYKCNHCEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFSGHSALLQHQRNHSEEKLN |
| 分子量 | 118.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF606蛋白的虚构参考文献示例(实际文献需通过学术数据库检索确认)：
1. **文献名称**：*ZNF606: A Novel Transcriptional Regulator in Human Stem Cells*
**作者**：Wang X, et al.
**摘要**：本研究构建了重组人ZNF606蛋白，发现其在干细胞分化中通过结合特定启动子区域抑制靶基因表达，提示其在维持干细胞多能性中的潜在作用。
2. **文献名称**：*Structural and Functional Analysis of Recombinant ZNF606 Protein*
**作者**：Smith JL, et al.
**摘要**：通过大肠杆菌系统表达并纯化重组ZNF606蛋白，结合X射线晶体学解析其锌指结构域，揭示其DNA结合模式及突变对功能的影响。
3. **文献名称**：*ZNF606 Overexpression Suppresses Tumor Growth in Breast Cancer Models*
**作者**：Kim H, et al.
**摘要**：在乳腺癌细胞中过表达重组ZNF606蛋白可下调致癌基因表达，抑制细胞增殖并促进凋亡，表明其可能作为肿瘤抑制因子。
4. **文献名称**：*Interactions Between ZNF606 and Chromatin Remodeling Complexes*
**作者**：Gomez R, et al.
**摘要**：研究发现重组ZNF606蛋白与SWI/SNF染色质重塑复合物相互作用，参与调控表观遗传修饰及基因沉默过程。
**备注**：若实际检索文献不足，建议扩大关键词(如“ZNF606 recombinant protein”或“ZNF606 function”)，或关注相关锌指蛋白家族研究作为间接参考。
Zinc finger protein 606 (ZNF606) is a member of the zinc finger protein family, characterized by conserved C2H2-type zinc finger motifs that mediate sequence-specific interactions with DNA or RNA. As a transcription factor, ZNF606 is postulated to play roles in regulating gene expression, though its precise biological functions remain poorly characterized. The human ZNF606 gene is located on chromosome 19 (19q13.43) and encodes a protein predominantly expressed in tissues such as the brain, testis, and liver, suggesting tissue-specific regulatory activities. Recombinant human ZNF606 protein is typically engineered using heterologous expression systems (e.g., E. coli or mammalian cells) to enable functional studies. Its modular zinc finger domains are predicted to bind specific DNA sequences, potentially influencing transcriptional repression or activation. Current research implicates ZNF606 in developmental processes and disease pathways, including cancer, though mechanistic insights are limited. Studies employing recombinant ZNF606 aim to delineate its DNA-binding specificity, protein interaction networks, and roles in cellular processes like proliferation and differentiation. Despite emerging interest, ZNF606 remains understudied compared to other zinc finger proteins, highlighting the need for further exploration of its molecular mechanisms and therapeutic relevance in human health and disease.
×
