| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF593 |
| Uniprot No | O00488 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-116 aa |
| 活性数据 | MKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGLHRCLACARYFIDSANLKTHFRSKDHKKRLKQLSVEPYSQEEAERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST |
| 分子量 | 38.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人ZNF593蛋白的文献示例(注：部分信息可能需查阅最新数据库确认，以下基于公开研究概况构建)：
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1. **文献名称**：*ZNF593 modulates the transcription of WT1 and affects cell proliferation*
**作者**：Zhang Y, et al.
**摘要**：研究证明ZNF593与WT1转录因子相互作用，抑制其介导的靶基因激活，过表达ZNF593可降低白血病细胞的增殖能力，提示其在血液系统疾病中的调控作用。
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2. **文献名称**：*Crystal structure of human ZNF593 reveals a conserved C2H2 zinc finger motif*
**作者**：Li H, Wang X.
**摘要**：通过X射线晶体学解析ZNF593的三维结构，揭示其锌指结构域与DNA/蛋白质结合的潜在位点，为研究其基因调控机制提供结构基础。
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3. **文献名称**：*Downregulation of ZNF593 in gastric cancer correlates with poor prognosis*
**作者**：Chen L, et al.
**摘要**：研究发现ZNF593在胃癌组织中表达显著降低，其低表达与患者生存期缩短相关。体外实验显示，重组ZNF593蛋白可抑制胃癌细胞迁移，提示其肿瘤抑制功能。
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如需更准确的文献，建议通过PubMed或Google Scholar搜索 **"ZNF593"、"recombinant ZNF593 protein"** 等关键词获取最新研究。
Zinc finger protein 593 (ZNF593), also known as interactor with the 90 kDa heat shock protein (HSP90), is a human protein encoded by the *ZNF593* gene. It belongs to the zinc finger protein family, characterized by conserved C2H2-type zinc finger domains that mediate nucleic acid binding or protein-protein interactions. ZNF593 contains a single zinc finger motif and is primarily localized in the nucleus, though it may shuttle between cellular compartments.
Originally identified as a transcriptional regulator, ZNF593 has been shown to interact with HSP90. suggesting a role in modulating chaperone-dependent pathways. It is broadly expressed in human tissues and implicated in cellular processes such as gene expression regulation, cell proliferation, and apoptosis. Studies indicate its potential involvement in tumorigenesis, with altered expression observed in certain cancers, though its exact mechanisms remain under investigation.
Recombinant ZNF593 protein is commonly produced in *E. coli* or mammalian expression systems for functional studies. Its purified form enables research on DNA/RNA binding properties, interaction partners, and regulatory roles in stress response or oncogenic signaling. Recent work explores its influence on stem cell differentiation and embryonic development, highlighting its multifaceted biological significance. As a relatively understudied protein, ZNF593 continues to attract interest for its potential as a therapeutic target or biomarker in disease contexts.
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