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Recombinant  Human TSR1 Protein

  • 中文名: 重组人(TSR1)蛋白
  • 别    名: TSR1; KIAA1401; Pre-rRNA-processing Protein TSR1 homolog
货号: PAX2000-12229
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TSR1
Uniprot NoQ2NL82
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-804 aa
活性数据MAAHRPGPLKQQNKAHKGGRHRGRGSAQRDGKGRLALKTLSKKVRKELSRVDQRHRASQLRKQKKEAVLAEKRQLGGKDGPPHQVLVVPLHSRISLPEAMQLLQDRDTGTVHLNELGNTQNFMLLCPRLKHRWFFTSARPGDLHVVLDMAKVADTILFLLDPLEGWDSTGDYCLSCLFAQGLPTYTLAVQGISGLPLKKQIDTRKKLSKAVEKRFPHDKLLLLDTQQEAGMLLRQLANQKQQHLAFRDRRAYLFAHAVDFVPSEENNLVGTLKISGYVRGQTLNVNRLLHIVGYGDFQMKQIDAPGDPFPLNPRGIKPQKDPDMAMEICATDAVDDMEEGLKVLMKADPGRQESLQAEVIPDPMEGEQTWPTEEELSEAKDFLKESSKVVKKVPKGTSSYQAEWILDGGSQSGGEGDEYEYDDMEHEDFMEEESQDESSEEEEEYETMTIGESVHDDLYDKKVDEEAEAKMLEKYKQERLEEMFPDEVDTPRDVAARIRFQKYRGLKSFRTSPWDPKENLPQDYARIFQFQNFTNTRKSIFKEVEEKEVEGAEVGWYVTLHVSEVPVSVVECFRQGTPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEELIFHCGFRRFRASPLFSQHTAADKHKLQRFLTADMALVATVYAPITFPPASVLLFKQKSNGMHSLIATGHLMSVDPDRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGHMKCSFDGKLKSQDTVLMNLYKRVFPKWTYDPYVPEPVPWLKSEISSTVPQGGME
分子量118.2 kDa
蛋白标签GST-tag at N-terminal
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是假设性的重组人TSR1蛋白相关文献示例(注:TSR1蛋白的具体功能需结合上下文,以下内容为模拟生成,仅供参考):

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1. **文献名称**: "Recombinant Human TSR1 Protein Inhibits Angiogenesis via CD36 Receptor Binding"

**作者**: Smith A, et al.

**摘要**: 本研究成功在大肠杆菌中表达了重组人TSR1蛋白(含Thrombospondin-1型重复结构域),并证明其通过结合内皮细胞表面CD36受体抑制血管生成,可能为抗肿瘤治疗提供新策略。

2. **文献名称**: "Functional Characterization of Recombinant TSR1 in Extracellular Matrix Remodeling"

**作者**: Lee B, et al.

**摘要**: 通过哺乳动物细胞系统表达重组TSR1蛋白,发现其通过调节MMP-2活性参与细胞外基质重塑,促进伤口愈合过程中的成纤维细胞迁移。

3. **文献名称**: "TSR1 as a Ribosome Biogenesis Factor: Insights from Recombinant Protein Studies"

**作者**: Gonzalez C, et al.

**摘要**: 利用杆状病毒系统制备重组人TSR1蛋白,证实其与18S rRNA前体结合,在核糖体亚基成熟中发挥关键作用,突变体导致核仁功能异常。

4. **文献名称**: "Structural Analysis of TSR1 Domain Interaction with TGF-β Pathway Components"

**作者**: Wang X, et al.

**摘要**: 通过重组TSR1蛋白晶体结构解析,揭示其与TGF-β受体特异性结合,负向调控SMAD信号通路,为纤维化疾病治疗提供结构基础。

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**注**:实际文献需通过PubMed等数据库以准确关键词(如“TSR1 protein recombinant human”)检索确认,上述内容为示例性生成。若TSR1指代其他蛋白,需结合具体基因名或功能修正检索策略。


背景信息

**Background of Recombinant Human TSR1 Protein**

TSR1 (T cell-specific protein 1) is a conserved eukaryotic protein primarily involved in ribosome biogenesis and RNA processing. Structurally, it contains tandem THN (TSP1-homology nuclear) domains, which mediate interactions with RNA or protein partners. Studies highlight its role in the maturation of 18S ribosomal RNA (rRNA) during the assembly of the 40S ribosomal subunit, a critical step in protein synthesis. TSR1 facilitates cleavage events in the precursor rRNA and assists in the structural reorganization of ribosomal components, often collaborating with other ribosome assembly factors like ENP1 or RIOK1. Dysregulation of TSR1 is linked to developmental disorders and cancers, emphasizing its biological significance.

Recombinant human TSR1 protein is typically produced using expression systems like *E. coli* or mammalian cells, enabling large-scale purification for research. The recombinant form retains functional domains, allowing studies on its molecular interactions, enzymatic activity, and structural contributions to ribosome assembly. Applications include *in vitro* ribosome reconstitution assays, RNA-protein binding experiments, and screening for inhibitors targeting ribosomopathies. Its recombinant production also aids in elucidating pathogenic mutations found in genetic disorders such as Diamond-Blackfan anemia. Overall, TSR1 serves as a vital tool for dissecting ribosome biogenesis mechanisms and exploring therapeutic strategies for related diseases.


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