| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRIM31 |
| Uniprot No | Q9BZY9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-425 aa |
| 活性数据 | MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF FKCPLCKTSV RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE MFHYFCEDDG KFLCFVCRES KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ QKEKETVQVK AQGVHRVDVF TDQVEHEKQR ILTEFELLHQ VLEEEKNFLL SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN MPPRQLLEDI KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP NHHSSAPSHS LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL SEELHAALSE WLTAIRAWFC EVPSS |
| 分子量 | 48.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **文献名称**: *TRIM31 promotes innate immunity against enterovirus 71 infection*
**作者**: Wang Y, et al.
**摘要**: 研究发现TRIM31通过调控MAVS信号通路增强宿主对肠道病毒71型的先天免疫应答，抑制病毒复制(《Nature Communications》, 2020)。
2. **文献名称**: *TRIM31 drives tumor progression via modulation of EGFR/AMPK signaling in hepatocellular carcinoma*
**作者**: Li X, et al.
**摘要**: 揭示TRIM31在肝癌中通过激活EGFR/AMPK通路促进肿瘤生长及转移，其表达与患者不良预后相关(《Cell Death & Disease》, 2019)。
3. **文献名称**: *TRIM31 suppresses NLRP3 inflammasome activation by promoting autophagy in macrophages*
**作者**: Zhang Z, et al.
**摘要**: 阐明TRIM31通过增强巨噬细胞自噬抑制NLRP3炎症小体活化，减轻炎症性疾病(《Journal of Immunology》, 2021)。
4. **文献名称**: *TRIM31 deficiency exacerbates obesity-induced cardiomyopathy via mitochondrial dysfunction*
**作者**: Chen J, et al.
**摘要**: 发现TRIM31通过调控线粒体自噬(mitophagy)减轻肥胖导致的心肌损伤，缺乏TRIM31加剧代谢紊乱相关心脏病变(《Diabetes》, 2018)。
注：以上信息为模拟示例，实际文献需通过PubMed/Google Scholar按关键词检索。
TRIM31. a member of the tripartite motif (TRIM) protein family, is an E3 ubiquitin ligase characterized by its conserved RING finger, B-box, and coiled-coil domains. Primarily localized to mitochondria, TRIM31 plays multifaceted roles in innate immunity, inflammatory responses, and cellular homeostasis. It modulates immune signaling pathways by ubiquitinating key proteins, such as NLRP3 inflammasome components, to regulate inflammasome activation and cytokine secretion (e.g., IL-1β). TRIM31 also interacts with viral proteins, restricting RNA virus replication (e.g., enteroviruses) through degradation or activity inhibition, highlighting its antiviral potential.
In disease contexts, TRIM31 exhibits dual roles. It may act as a tumor suppressor by promoting apoptosis (e.g., in gastric cancer via p53 stabilization) or exert oncogenic effects depending on cellular context. Dysregulation of TRIM31 is linked to inflammatory bowel disease (IBD), where it mitigates intestinal inflammation by suppressing excessive autophagy and NLRP3 activation. Additionally, TRIM31 participates in metabolic regulation, influencing insulin signaling and fatty acid oxidation. Despite these advances, its precise mechanistic contributions to specific diseases remain under investigation. Recent studies also explore its therapeutic potential, particularly in targeting inflammation-related disorders and viral infections. Ongoing research aims to clarify tissue-specific functions and post-translational modifications governing its activity.
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