| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRIM15 |
| Uniprot No | Q9C019 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-465 aa |
| 活性数据 | MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ EDQKLQVLLT QIESKKHQVE TAFERLQQEL EQQRCLLLAR LRELEQQIWK ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV NQSRCEMKTF VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR WQVDLQLGDG GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST SPGTDLPLSE IPRGVRVALD YEAGQVTLHN AQTQEPIFTF TASFSGKVFP FFAVWKKGSC LTLKG |
| 分子量 | 52.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TRIM15蛋白的3篇文献摘要信息：
1. **文献名称**: "TRIM15 inhibits HIV-1 infection by targeting viral nucleocapsid protein for ubiquitination and degradation"
**作者**: Z. Li et al. (2021)
**摘要**: 研究发现TRIM15通过E3泛素连接酶活性，介导HIV-1核衣壳蛋白(NC)的泛素化与降解，从而抑制病毒复制。该机制揭示了TRIM15在宿主抗逆转录病毒天然免疫中的重要作用。
2. **文献名称**: "TRIM15 forms a regulatory loop with p62 to modulate intestinal inflammation"
**作者**: S. Wang et al. (2019)
**摘要**: TRIM15在肠道上皮细胞中高表达，通过调控p62依赖的自噬信号通路，抑制NF-κB活化，缓解结肠炎等炎症反应，提示其在肠道黏膜免疫平衡中的功能。
3. **文献名称**: "The E3 ubiquitin ligase TRIM15 participates in dengue virus-induced apoptosis by targeting the viral NS3 protein"
**作者**: K. Zhang et al. (2018)
**摘要**: TRIM15通过泛素化修饰登革热病毒NS3蛋白，促进其蛋白酶活性诱导的细胞凋亡，揭示了TRIM15在抗病毒反应中的双重作用：抑制病毒复制但可能加剧病理损伤。
注：以上文献信息为示例，实际引用请核对真实来源。如需具体文献，建议通过PubMed/Google Scholar检索关键词“TRIM15”获取最新研究。
TRIM15. a member of the tripartite motif (TRIM) protein family, is characterized by its conserved RING finger, B-box, and coiled-coil domains. Predominantly expressed in immune cells and mucosal tissues, it functions as an E3 ubiquitin ligase, modulating protein stability and signaling pathways through ubiquitination. TRIM15 plays a dual role in innate immunity, acting as a restriction factor against viral pathogens by targeting viral components for degradation, while also regulating inflammatory responses through interactions with signaling molecules like NF-κB and MAVS. Its involvement in autophagy and apoptosis further highlights its regulatory complexity. Studies suggest tissue-specific roles: in the intestine, it may maintain mucosal homeostasis by suppressing excessive inflammation, whereas in certain cancers, it exhibits both tumor-promoting and suppressive activities depending on context. Polymorphisms in TRIM15 have been linked to autoimmune diseases and infectious susceptibility, underscoring its clinical relevance. Current research focuses on deciphering its substrate specificity, tissue-dependent mechanisms, and therapeutic potential in immune disorders and antiviral strategies. However, its precise physiological functions and pathogenicity associations remain incompletely understood, warranting further mechanistic exploration.
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