| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRIM26 |
| Uniprot No | Q12899 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-539 aa |
| 活性数据 | MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP |
| 分子量 | 62.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TRIM26蛋白的3篇参考文献及其摘要概括：
1. **"TRIM26 is a critical host factor against HIV-1 by promoting ubiquitination of viral Gag and enhancing innate immune response"**
- 作者：Zhang et al. (2020)
- 摘要：该研究揭示了TRIM26通过泛素化HIV-1病毒的Gag蛋白，促进病毒颗粒的降解并激活宿主细胞的抗病毒先天免疫通路(如STING-IRF3通路)，从而抑制HIV复制。
2. **"TRIM26 suppresses colorectal cancer progression through destabilizing HIF-1α and promoting tumor cell apoptosis"**
- 作者：Wang et al. (2019)
- 摘要：研究发现TRIM26在结直肠癌中低表达，其通过介导HIF-1α蛋白的泛素化降解抑制肿瘤缺氧适应，并促进癌细胞凋亡，提示TRIM26的抑癌作用可能成为治疗靶点。
3. **"TRIM26 modulates antiviral immune response through ubiquitination of cGAS and MAVS"**
- 作者：Li et al. (2021)
- 摘要：该论文发现TRIM26通过K63-linked泛素化修饰先天免疫信号分子cGAS和MAVS，增强抗病毒信号通路活性(如I型干扰素产生)，同时负向调控炎症因子风暴，平衡免疫应答。
备注：以上文献为示例性内容，实际文献名称及结论需根据真实论文调整。建议通过PubMed或Web of Science以“TRIM26”为关键词检索最新研究。
TRIM26 (Tripartite Motif-containing protein 26) is a member of the TRIM family, characterized by conserved RING, B-box, and coiled-coil domains. Located on human chromosome 6 (6p22.1), it plays diverse roles in innate immunity, antiviral responses, and immune regulation. As an E3 ubiquitin ligase, TRIM26 mediates substrate ubiquitination to modulate protein stability, localization, or interaction networks. It is notably involved in regulating interferon (IFN) signaling and NF-κB pathways, influencing antiviral defense mechanisms. TRIM26 also associates with MHC class I antigen presentation by targeting proteasomal components.
Studies highlight its dual roles in cancer: it may act as a tumor suppressor by promoting degradation of oncoproteins (e.g., YAP/TAZ) or as a tumor promoter in certain contexts via stabilizing pro-survival factors. TRIM26 interacts with viral proteins (e.g., HIV-1 integrase, influenza NS1) to inhibit viral replication or facilitate immune evasion. Its expression is dynamically regulated during viral infections and inflammatory conditions. Despite its emerging significance, TRIM26's precise molecular mechanisms and tissue-specific functions remain under investigation, with potential therapeutic implications for antiviral strategies and cancer immunotherapy.
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