| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TPD52L2 |
| Uniprot No | O43399 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-206 aa |
| 活性数据 | MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYVKTS EKLGEWNEKV TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA ISRKLGDMRN SATFKSFEDR VGTIKSKVVG DRENGSDNLP SSAGSGDKPL SDPAPF |
| 分子量 | 22.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TPD52L2蛋白的3-4篇参考文献摘要的简要整理，基于公开文献模拟(可能存在部分信息不全)：
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1. **文献名称**: *The TPD52 family of proteins: A review of their roles in cancer and cellular mechanisms*
**作者**: Byrne JA, et al.
**摘要**: 本研究综述了TPD52家族蛋白(包括TPD52L2)在肿瘤发生中的功能。研究发现，TPD52L2在乳腺癌、前列腺癌等多种癌症中过表达，重组蛋白的体外实验表明其通过调节细胞增殖、凋亡相关信号通路(如MAPK和PI3K/AKT)促进肿瘤进展。
2. **文献名称**: *Recombinant TPD52L2 as a potential diagnostic biomarker for colorectal cancer*
**作者**: Chen L, et al.
**摘要**: 作者通过重组表达TPD52L2蛋白并制备多克隆抗体，发现其在结直肠癌患者血清中显著高表达。该研究利用重组蛋白建立ELISA检测方法，提出TPD52L2可能作为新型癌症诊断标志物。
3. **文献名称**: *TPD52L2 interacts with RAB5A to regulate endosomal trafficking and cancer cell invasion*
**作者**: Lee S, et al.
**摘要**: 通过重组人TPD52L2蛋白的体外结合实验，本研究揭示了其与RAB5A的相互作用机制，证明这一互作通过调控内体运输促进肿瘤细胞的迁移和侵袭，为靶向治疗提供了理论依据。
4. **文献名称**: *Overexpression of recombinant human TPD52L2 enhances chemoresistance in ovarian cancer cells*
**作者**: Zhang Y, et al.
**摘要**: 研究通过重组TPD52L2转染卵巢癌细胞，发现其表达上调可增加细胞对顺铂的耐药性，机制可能与抑制ROS积累和激活抗凋亡蛋白BCL-2有关。
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**注意**：以上文献信息为模拟示例，实际引用需核实真实发表的论文及细节。建议通过PubMed、Web of Science等数据库，以“TPD52L2”、“recombinant protein”等关键词检索最新文献。
Recombinant human TPD52L2 protein is a genetically engineered form of the tumor protein D52-like 2 (TPD52L2), a member of the TPD52 family implicated in cell proliferation, apoptosis, and vesicle trafficking. TPD52L2 shares conserved structural features with other family members, including coiled-coil domains that mediate protein interactions. It is broadly expressed in tissues and localizes to the Golgi apparatus and cytoplasm, where it regulates secretory pathways, calcium signaling, and membrane dynamics.
Studies link TPD52L2 to cancer progression, with overexpression observed in breast, prostate, and lung cancers, where it may enhance metastatic potential by modulating epithelial-mesenchymal transition (EMT) or survival pathways like PI3K/AKT. Its role in lipid metabolism and exosome biogenesis further underscores its oncogenic relevance. Recombinant TPD52L2. typically produced in bacterial or mammalian systems, retains functional epitopes and post-translational modifications, enabling mechanistic studies. Researchers use it to investigate binding partners (e.g., calmodulin), signaling cascades, and its impact on tumor aggressiveness. Additionally, it serves as an antigen for antibody development in diagnostic or therapeutic applications. Despite progress, TPD52L2's precise regulatory mechanisms and tissue-specific functions remain under exploration, highlighting its potential as a biomarker or target in precision oncology.
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