| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLC27A6 |
| Uniprot No | Q9Y2P4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-619 aa |
| 活性数据 | MLLSWLTVLGAGMVVLHFVQKLLFTYFWDDFWFVLKVVLIIIRLKKYEKRGELVTVLDKFLSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLIKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL |
| 分子量 | 93.83 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人SLC27A6蛋白的3篇参考文献及其摘要概括：
1. **文献名称**: "Functional characterization of recombinant human fatty acid transport protein 6 (SLC27A6) in cellular lipid metabolism"
**作者**: Doe, J. et al.
**摘要**: 该研究通过在大肠杆菌中重组表达SLC27A6蛋白，证实其在细胞中对长链脂肪酸的摄取和酯化具有关键作用，并揭示其通过调控PPAR通路影响脂代谢的机制。
2. **文献名称**: "Crystal structure of the human fatty acid transport protein SLC27A6"
**作者**: Smith, R. et al.
**摘要**: 利用昆虫细胞系统重组表达人SLC27A6蛋白，解析其三维结构，发现其独特的跨膜结构域可能介导脂肪酸的翻转运输，为靶向药物设计提供结构基础。
3. **文献名称**: "SLC27A6 regulates triglyceride synthesis through recombinant protein-mediated fatty acid uptake assays"
**作者**: Lee, H. et al.
**摘要**: 通过在哺乳动物细胞中表达重组SLC27A6.发现其与FATP4功能互补，参与肝脏甘油三酯合成调控，提示其在代谢综合征中的潜在病理作用。
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注：以上为示例文献。实际研究中建议通过PubMed或Web of Science以"SLC27A6 recombinant"等关键词检索最新文献。
**Background of Recombinant Human SLC27A6 Protein**
Solute Carrier Family 27 Member 6 (SLC27A6), also known as Fatty Acid Transport Protein 6 (FATP6), is a membrane-bound protein involved in fatty acid metabolism and transport. As a member of the SLC27 family, it plays a critical role in facilitating cellular uptake of long-chain fatty acids (LCFAs) by acting as an acyl-CoA synthetase, activating LCFAs for subsequent metabolic pathways. SLC27A6 is predominantly expressed in tissues with high fatty acid demand, such as the liver, small intestine, and placenta, suggesting its importance in lipid homeostasis and energy production.
Structurally, SLC27A6 contains an N-terminal transmembrane domain, a central ATP/AMP-binding motif, and a C-terminal fatty acid-binding domain. Its recombinant form is generated using expression systems like *E. coli* or mammalian cells, enabling studies on its enzymatic activity, substrate specificity, and interaction partners. Research highlights its potential involvement in metabolic disorders, such as obesity and diabetes, as dysregulation of fatty acid transport may contribute to lipid accumulation and insulin resistance.
Recombinant SLC27A6 protein serves as a vital tool for elucidating mechanisms of lipid metabolism, drug discovery targeting metabolic diseases, and understanding its tissue-specific roles. Its study also extends to cancer research, where altered fatty acid metabolism is linked to tumor progression. Further investigation into SLC27A6 could unlock therapeutic strategies for managing lipid-related pathologies.
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