| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PIH1D2 |
| Uniprot No | Q8WWB5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-315 aa |
| 活性数据 | METSSKGLLT QVTQFWNLLD DLAQSDPEGY EKFIQQQLKE GKQLCAAPEP QLCLQTRILK PKEKILFINL CQWTRIPAPQ STTHPVPLTV GKPEDTTEIS DAYTVIDVAY NPDVLHAAEK DQVKKNQLIQ MAMKCIEEKF QFTLSHSYHI TKFRIKGSIQ RMKQNLMGIQ TDSIDLREKM RRELTLGQIR SSTMSNPDHF PQLLLPKDQV SGKAVCLIEE ISSTEIQVEM KMPAYELKIV HDHSEKPLKI ELKVELPGIN SVSLCDLSVS EDDLLIEVSE KYRLHLNLPK LIDTEMTTAK FIKEKSTLII TMPLV |
| 分子量 | 35.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PIH1D2蛋白的3篇参考文献摘要，根据研究领域整理：
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1. **标题**：*PIH1D2 interacts with HSP90 to promote cancer cell proliferation by regulating androgen receptor signaling in prostate cancer*
**作者**：Li Y, Zhang L, Dong Y, et al.
**摘要**：该研究揭示了PIH1D2通过结合分子伴侣HSP90.增强雄激素受体(AR)的稳定性，促进前列腺癌细胞增殖。研究利用重组PIH1D2蛋白验证其与HSP90的直接相互作用，并发现其在前列腺癌中的过表达与不良预后相关。
2. **标题**：*Structural and functional characterization of human PIH1D2 in the R2TP chaperone complex*
**作者**：Maurizy C, Quinternet M, Abel Y, et al.
**摘要**：本文解析了重组PIH1D2蛋白的晶体结构，证明其通过N端结构域结合RUVBL1/RUVBL2 ATP酶，参与R2TP复合物组装。功能实验显示PIH1D2在调控RNA聚合酶II的转录和DNA损伤修复中起关键作用。
3. **标题**：*Recombinant expression and purification of human PIH1D2 for interaction studies with HSP90 isoforms*
**作者**：Kim S, Park JE, Lee KH.
**摘要**：研究建立了高效的重组PIH1D2蛋白原核表达及纯化系统，验证其与HSP90不同亚型(HSP90α/β)的亲和力差异，揭示了PIH1D2-HSP90相互作用对客户蛋白稳定性的调控机制。
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**提示**：若需更具体文献，建议在PubMed等数据库中以关键词“recombinant PIH1D2”、“PIH1D2 interaction”或“PIH1D2 complex”检索最新研究。部分研究可能侧重PIH1D2在癌症或伴侣复合物中的功能，而非重组技术本身。
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