| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MCTP2 |
| Uniprot No | Q6DN12 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-306aa |
| 活性数据 | MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAHRKEEPPLSMKCTLFSGDIGPSL |
| 分子量 | 59.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MCTP2蛋白的参考文献示例(基于公开文献归纳，部分信息可能需根据实际研究调整)：
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1. **标题**: *Structural and Functional Analysis of Recombinant Human MCTP2 Reveals Calcium-Dependent Lipid Binding Properties*
**作者**: Zhang L, et al.
**摘要**: 本研究通过大肠杆菌表达系统成功纯化了重组人MCTP2蛋白，并利用X射线晶体学解析其C2结构域的三维结构。实验表明MCTP2通过钙离子依赖性方式结合磷脂膜，提示其在细胞膜运输中的潜在作用。
2. **标题**: *MCTP2 Regulates Synaptic Vesicle Exocytosis via Interaction with SNARE Proteins*
**作者**: Tanaka K, et al.
**摘要**: 研究团队通过哺乳动物细胞表达重组人MCTP2.发现其与突触融合蛋白(如Syntaxin-1)直接相互作用，调控神经递质释放。该工作揭示了MCTP2在突触可塑性中的功能。
3. **标题**: *Aberrant Expression of MCTP2 in Breast Cancer and Its Role in Tumor Metastasis*
**作者**: Wang H, et al.
**摘要**: 通过制备重组MCTP2蛋白进行体外功能实验，发现其在乳腺癌细胞中高表达，并促进细胞迁移和侵袭。机制研究表明MCTP2通过激活ERK信号通路驱动转移。
4. **标题**: *A Novel Role of MCTP2 in Cardiac Calcium Handling and Arrhythmia*
**作者**: Patel R, et al.
**摘要**: 研究利用重组MCTP2蛋白探究其对心肌细胞钙离子调控的影响，发现MCTP2缺陷导致钙瞬变异常，可能与心律失常相关，为心脏疾病提供新靶点。
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**备注**：以上文献标题和作者为示例性内容，具体研究需以实际发表文献为准。若需真实文献，建议通过PubMed或Google Scholar以关键词“recombinant human MCTP2”或“MCTP2 protein function”检索最新文章。
Recombinant human MCTP2 (Multiple C2 and Transmembrane Domain Protein 2) is a protein engineered through molecular cloning and expression systems for research and therapeutic applications. The native MCTP2. encoded by the *MCTP2* gene in humans, belongs to a family of proteins characterized by multiple C2 domains and transmembrane regions. These structural features suggest roles in calcium-dependent membrane trafficking, cell signaling, or intercellular communication. The C2 domains are known to bind phospholipids in a Ca²⁺-dependent manner, while the transmembrane segments may anchor the protein to membranes or facilitate protein-protein interactions.
MCTP2 is expressed in various tissues, including the brain, heart, and skeletal muscle, though its precise biological functions remain under investigation. Studies link it to neural development, cardiovascular function, and potentially cancer progression. Dysregulation of MCTP2 has been implicated in congenital heart defects and neurodevelopmental disorders, making it a target for mechanistic and translational studies. Recombinant versions are produced in systems like *E. coli* or mammalian cell cultures to ensure proper post-translational modifications. These proteins enable in vitro studies on binding partners, signaling pathways, and structural analyses. Researchers also utilize recombinant MCTP2 to explore its role in calcium signaling dynamics and membrane repair processes, offering insights into cellular homeostasis and disease mechanisms.
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