| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1143 |
| Uniprot No | Q96AT1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-154aa |
| 活性数据 | MSKRNQVSYVRPAEPAFLARFKERVGYREGPTVETKRIQPQPPDEDGDHSDKEDEQPQVVVLKKGDLSVEEVMKIKAEIKAAKADEEPTPADGRIIYRKPVKHPSDEKYSGLTASSKKKKPNEDEVNQDSVKKNSQKQIKNSSLLSFDNEDENE |
| 分子量 | 43.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1143蛋白的3篇模拟参考文献(实际文献可能需要通过学术数据库检索验证)：
---
1. **文献名称**: *Functional Characterization of Recombinant Human KIAA1143 in Cell Migration*
**作者**: Li X. et al.
**摘要**: 研究通过HEK293细胞重组表达KIAA1143蛋白，发现其能够通过调节Rho GTPase信号通路促进细胞迁移，暗示其在肿瘤转移中的潜在作用。
---
2. **文献名称**: *Structural Analysis and Expression of KIAA1143 in Human Tissues*
**作者**: Tanaka K. et al.
**摘要**: 报道了重组KIAA1143蛋白的纯化方法及其晶体结构解析，显示其包含多个功能结构域，在脑和肾脏组织中高表达，可能与神经发育相关。
---
3. **文献名称**: *KIAA1143 Interacts with MAPK Signaling Pathway*
**作者**: Wang Y. et al.
**摘要**: 通过重组蛋白的体外实验证实KIAA1143与MAPK蛋白复合物结合，可能参与调控细胞应激反应和凋亡过程。
---
4. **文献名称**: *The Role of KIAA1143 in Inflammatory Diseases*
**作者**: Zhang R. et al.
**摘要**: 利用重组KIAA1143在小鼠模型中验证其通过NF-κB通路抑制炎症反应，表明其作为抗炎治疗靶点的潜力。
---
**提示**：以上为示例性模拟结果，实际研究需通过PubMed、Google Scholar等平台检索真实文献(可尝试关键词：recombinant KIAA1143. KIAA1143 function)。
**Background of Recombinant Human KIAA1143 Protein**
The KIAA1143 gene, also known as FAM234A, encodes a protein predominantly expressed in the brain and testes, with conserved roles across vertebrates. Although its precise molecular functions remain under investigation, emerging evidence suggests involvement in cellular processes such as cytoskeletal organization, intracellular trafficking, and signal transduction. Structural analyses reveal conserved domains indicative of protein-protein interaction capabilities, potentially linking it to pathways like Wnt or TGF-β signaling.
Dysregulation of KIAA1143 has been tentatively associated with neurological disorders, including intellectual disability and autism spectrum disorders, as well as certain cancers. Recombinant human KIAA1143 protein, typically produced in *E. coli* or mammalian expression systems, enables functional studies to elucidate its biological mechanisms. It serves as a critical tool for *in vitro* binding assays, antibody development, and disease modeling.
Current research focuses on clarifying its interaction networks, post-translational modifications, and therapeutic potential. The protein's conserved nature underscores its biological significance, driving efforts to unravel its role in health and disease. Further studies are needed to validate its pathophysiological relevance and explore applications in diagnostics or targeted therapies.
×
