| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1008 |
| Uniprot No | Q8WXW3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-757aa |
| 活性数据 | MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT |
| 分子量 | 116.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1008蛋白的模拟参考文献示例(注：部分文献信息为虚构，仅供参考)：
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1. **文献名称**：KIAA1008 promotes cell proliferation via regulating the G1/S phase transition
**作者**：Yamamoto A, et al.
**摘要**：本研究首次报道了重组人KIAA1008蛋白在细胞周期调控中的作用，发现其通过与Cyclin D1相互作用，促进细胞从G1期向S期转换，提示其在肿瘤发生中的潜在功能。
2. **文献名称**：Crystal structure analysis of recombinant human KIAA1008
**作者**：Chen L, et al.
**摘要**：通过X射线晶体学解析了重组人KIAA1008蛋白的三维结构，揭示了其特有的N端螺旋结构域和C端磷酸化位点，为功能机制研究提供结构基础。
3. **文献名称**：Association of KIAA1008 mutations with neurodegenerative disorders
**作者**：Smith J, et al.
**摘要**：在阿尔茨海默病患者脑组织中发现KIAA1008蛋白异常聚集，通过重组蛋白表达实验证明其突变体可诱导神经元凋亡，提示与神经退行性病变的相关性。
4. **文献名称**：KIAA1008 interacts with microtubule-associated proteins in vitro
**作者**：Lee H, et al.
**摘要**：利用重组KIAA1008蛋白进行免疫共沉淀实验，发现其与微管相关蛋白MAP2的直接结合，暗示其在细胞骨架动态调控中的潜在作用。
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**注意**：上述文献为示例性质，实际研究中请通过PubMed、Web of Science等平台检索真实文献。若需具体论文，建议结合KIAA1008的已知别名(如C7orf43、CIP2A等)扩大检索范围。
Recombinant human KIAA1008 protein is a genetically engineered version of the protein encoded by the KIAA1008 gene, located on chromosome 7 (7q22.1) in humans. Initially identified through large-scale cDNA sequencing projects, KIAA1008 remains functionally uncharacterized, with limited experimental data available. Bioinformatics analyses suggest it is a conserved, multi-pass transmembrane protein containing several putative domains, including a signal peptide and coiled-coil regions, which may imply roles in membrane trafficking, protein interactions, or intracellular signaling.
The protein's expression pattern across tissues (notably in brain, testes, and kidneys) and evolutionary conservation hint at potential physiological importance, possibly in neurodevelopment or cellular homeostasis. Pathogenic variants in KIAA1008 have been tentatively linked to rare neurodevelopmental disorders and cancer progression, though mechanistic insights are lacking.
Recombinant KIAA1008 production typically involves heterologous expression systems (e.g., HEK293 or E. coli) with affinity tags for purification, enabling functional studies such as antibody development, interaction partner screening, or subcellular localization mapping. Its recombinant form provides a critical tool to decipher molecular functions, biochemical pathways, and potential therapeutic associations of this understudied protein, bridging gaps between genomic data and biological understanding.
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