| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA0907 |
| Uniprot No | Q7Z7F0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-614aa |
| 活性数据 | MSAGSATHPGAGGRRSKWDQPAPAPLLFLPPAAPGGEVTSSGGSPGGTTAAPSGALDAAAAVAAKINAMLMAKGKLKPTQNASEKLQAPGKGLTSNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGTSPTFNGATVTVYHQPAPIAQLSPAVSQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQINTAVPLPGYTQPSAISSVPPQPPYYPSNGYQSGYPVVPPPQQPVQPPYGVPSIVPPAVSLAPGVLPALPTGVPPVPTQYPITQVQPPASTGQSPMGGPFIPAAPVKTALPAGPQPQPQPQPPLPSQPQAQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQNEIEGAGSKPASSSGKERERDRQLMPPPAFPVTGIKTESDERNGSGTLTGSHDYPAKKMKTTEKGFGLVAYAADSSDEEEEHGGHKNASSFPQGWSLGYQYPSSQPRAKQQMPFWMAP |
| 分子量 | 91.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA0907蛋白的模拟参考文献示例(非真实文献，仅供格式参考)：
1. **文献名称**：**"Expression and Functional Analysis of Recombinant Human KIAA0907 in HEK293 Cells"**
**作者**：Zhang L. et al.
**摘要**：本研究成功在HEK293细胞中表达并纯化了重组人KIAA0907蛋白，发现其通过调控Wnt/β-catenin信号通路抑制肿瘤细胞迁移。实验表明，KIAA0907过表达可显著降低结肠癌细胞侵袭能力。
2. **文献名称**：**"KIAA0907 Protein Interacts with mTORC1 and Modulates Autophagy Pathways"**
**作者**：Wang Y. et al.
**摘要**：通过免疫共沉淀和质谱分析，研究发现重组人KIAA0907蛋白与mTORC1复合物直接结合，并在营养胁迫条件下促进自噬，提示其在细胞代谢应激中的潜在作用。
3. **文献名称**：**"Structural Characterization of Recombinant KIAA0907 and Its Role in Neuronal Development"**
**作者**：Smith J. et al.
**摘要**：通过X射线晶体学解析了重组人KIAA0907蛋白的C端结构域，发现其通过磷酸化依赖的方式参与神经元突触形成，敲低KIAA0907导致小鼠脑神经元分支减少。
4. **文献名称**：**"KIAA0907 Acts as a Tumor Suppressor via p53 Stabilization in Glioblastoma"**
**作者**：Chen H. et al.
**摘要**：研究表明，重组人KIAA0907蛋白可通过直接结合并稳定p53蛋白抑制胶质母细胞瘤细胞增殖，体内实验验证其过表达能显著延长荷瘤小鼠生存期。
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提示：实际文献建议通过 **PubMed/Google Scholar** 以关键词 **"KIAA0907 protein"** 或 **"KNDC1 (别名)"** 结合 **"recombinant expression"** 等筛选近年研究。
KIAA0907. also known as MXRA7 (matrix-remodeling-associated protein 7), is a human protein encoded by the KIAA0907 gene. Initially identified through large-scale sequencing projects, its functional characterization remains limited. Structurally, it contains putative coiled-coil domains and a transmembrane region, suggesting roles in protein interactions or membrane-associated processes. Studies localize it to the cytoplasm and nucleus, with potential involvement in extracellular matrix (ECM) remodeling, cell adhesion, or signaling pathways.
The recombinant form of KIAA0907 protein is typically produced in heterologous expression systems (e.g., E. coli or mammalian cells) for biochemical studies. Its recombinant expression enables investigation of post-translational modifications, interactome mapping, and structural analysis. Emerging evidence links KIAA0907 to cancer progression and fibrosis, possibly through ECM modulation, though mechanistic details are unclear. In some contexts, it appears upregulated in tumor tissues, hinting at diagnostic or therapeutic potential.
Phylogenetic analyses reveal conserved homologs across vertebrates, underscoring its biological significance. Current research focuses on elucidating its molecular partners, enzymatic activities (if any), and regulatory roles in tissue homeostasis. The lack of KO models or functional antibodies continues to challenge comprehensive biological validation. Recombinant KIAA0907 serves as a critical tool to address these gaps and explore its implications in development and disease pathology.
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