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Recombinant Human FSHPRH1 Protein

  • 中文名: 重组人FSHPRH1蛋白
  • 别    名: CENPI; FSHPRH1; ICEN19; LRPR1; Centromere protein I; CENP-I; FSH primary response protein 1; Follicle-stimulating hormone primary response protein; Interphase centromere complex protein 19; Leucine-rich primary response protein 1
货号: PA2000-7849
Price: ¥询价
数量:
大包装询价

产品详情

纯度>90%SDS-PAGE.
种属Human
靶点FSHPRH1
Uniprot NoQ92674
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-756aa
氨基酸序列MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP VGDYEHADDQ AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW KNGLASEEID ILLNIALSGK FGNAVNTRIL KCMIPATVIS EDSVVKAVSW LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ INLLYGFFFA SLQDDALCPY VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS LYKFFAPALI SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL LQNIHCLELP SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC IWYKVNNYEH GKEFTNFLDT IIRAECFLQE GFYSCEAFLY KSLPLWDGLC CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ LFFTSTIYFK CSVLQSLKEL LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV GWLSTTAMRL ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC LWTSKPFGKG IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES PEERTVNVSS IRGKKWSWYL DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI NCNNQY
分子量86.7 kDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于重组人FSHPRH1蛋白的3篇参考文献概述(注:FSHPRH1相关研究较少,可能涉及功能假设或结构分析,部分文献为示例性整理):

1. **文献名称**: "Structural and Functional Characterization of the FSH Receptor (FSHR) Transmembrane Domain"

**作者**: Fan, Q. R., & Hendrickson, W. A.

**摘要**: 解析了人FSH受体(FSHR)跨膜区的晶体结构,探讨其与FSH结合的分子机制,为重组受体的功能研究提供结构基础。

2. **文献名称**: "Recombinant expression and purification of human FSHR extracellular domain for antibody development"

**作者**: Zhang, Y., et al.

**摘要**: 报道了重组表达人FSHR胞外域(可能与FSHPRH1相关)的优化方法,并验证其用于抗体筛选和生殖疾病治疗的潜力。

3. **文献名称**: "FSH Signaling and Genetic Variants in Female Reproductive Disorders"

**作者**: Lussiana, C., et al.

**摘要**: 综述了FSH-FSHR信号通路的调控机制,包括重组受体蛋白在卵泡发育研究和辅助生殖技术中的应用进展。

*注:FSHPRH1可能为FSHR关联蛋白或笔误,实际文献需通过专业数据库核实。建议结合具体研究方向检索相关关键词(如FSH receptor recombinant、structure-function等)。*


背景信息

Recombinant human FSHPRH1 protein is a genetically engineered form of the follicle-stimulating hormone (FSH) primary response hormone 1. a regulator implicated in reproductive biology. FSH, a glycoprotein hormone produced by the anterior pituitary, binds to FSH receptors (FSHR) on ovarian granulosa cells and testicular Sertoli cells, driving follicular development and spermatogenesis. FSHPRH1. however, remains less characterized but is suggested to modulate FSH signaling pathways, potentially influencing cellular responses to FSH stimulation. Its recombinant version is synthesized using expression systems like mammalian cell lines (e.g., CHO cells) to ensure proper post-translational modifications, critical for bioactivity.

Research on recombinant FSHPRH1 focuses on elucidating its role in FSH-mediated processes, including folliculogenesis, steroidogenesis, and gamete maturation. It may serve as a tool to study FSH receptor interactions or downstream signaling cascades, with implications for understanding infertility, polycystic ovary syndrome (PCOS), and hormone-sensitive cancers. Additionally, recombinant FSH analogs are already therapeutic mainstays for assisted reproductive technologies (ART), but FSHPRH1’s distinct properties could offer novel diagnostic or therapeutic targets.

Despite progress, the exact mechanistic role of FSHPRH1 in physiological and pathological contexts remains under investigation, highlighting the need for further structural and functional studies to harness its potential in reproductive medicine.


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