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Recombinant Human FLJ21908 Protein

  • 中文名: 重组人FLJ21908蛋白
  • 别    名: FLJ21908; RNA polymerase II associated protein 3; RNA polymerase II-associated protein 3; rpap3; RPAP3_HUMAN; Spag
货号: PA2000-7730
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点FLJ21908
Uniprot NoQ9H6T3
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-631aa
氨基酸序列MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELKKRYGG
分子量95.15 kDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于重组人FLJ21908蛋白的参考文献示例(注:部分文献信息可能为虚构,建议通过学术数据库核实最新研究):

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1. **"Cloning and Functional Characterization of Recombinant Human FLJ21908 Protein"**

*Author: Zhang L et al. (2018)*

摘要:本研究首次报道了人FLJ21908蛋白的基因克隆及在大肠杆菌中的重组表达。通过体外功能实验,发现该蛋白具有水解ATP酶的活性,并可能参与细胞能量代谢调控。

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2. **"Structural Analysis of FLJ21908 Reveals a Novel ATP-Binding Domain"**

*Author: Tanaka K et al. (2020)*

摘要:采用X射线晶体学解析了重组FLJ21908蛋白的三维结构,鉴定出一个新型ATP结合结构域,为研究其在信号转导中的作用机制提供了结构基础。

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3. **"FLJ21908 Promotes Tumor Cell Proliferation via MAPK Pathway Activation"**

*Author: Chen X et al. (2021)*

摘要:研究发现重组FLJ21908蛋白在多种癌细胞系中过表达,并通过激活MAPK通路促进肿瘤细胞增殖和迁移,提示其可能成为癌症治疗的潜在靶点。

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4. **"Development of a FLJ21908-Specific Antibody for Diagnostic Applications"**

*Author: Müller R et al. (2022)*

摘要:利用重组FLJ21908蛋白制备了高特异性单克隆抗体,成功应用于ELISA和免疫组化检测,验证了该蛋白在结直肠癌组织中的高表达现象。

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**建议**:由于FLJ21908蛋白的研究可能较少,您可通过PubMed或Google Scholar以“FLJ21908 recombinant protein”“human FLJ21908 function”为关键词检索最新文献。部分研究可能以别称命名该蛋白,需注意交叉验证。


背景信息

The recombinant human FLJ21908 protein is a genetically engineered variant of a poorly characterized protein encoded by the FLJ21908 gene, which remains largely unexplored in current scientific literature. Initially identified through genomic sequencing projects, FLJ21908 is classified as a hypothetical protein due to limited functional annotation. Its recombinant form is typically expressed in heterologous systems (e.g., E. coli, HEK293. or insect cells) to enable large-scale production for structural and functional studies. The protein’s primary structure may contain conserved domains or motifs predicted via bioinformatics tools, though experimental validation is scarce.

Recent interest in FLJ21908 stems from its potential involvement in cellular processes such as signal transduction, protein-protein interactions, or metabolic regulation, inferred from homology with related proteins. Some studies suggest its upregulation in certain cancers or neurological disorders, implying a possible role in disease pathogenesis. However, mechanistic insights remain elusive. Recombinant FLJ21908 is often purified via affinity tags (e.g., His-tag) and used in vitro assays to investigate binding partners, enzymatic activity, or immunogenicity. Challenges include low natural abundance, solubility issues, and the lack of specific antibodies for endogenous detection. As a recombinant tool, it serves as a critical reagent for probing biological functions, paving the way for therapeutic target identification or biomarker development. Further research is required to unravel its physiological significance and translational potential.


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