| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FLJ21019 |
| Uniprot No | Q7Z736 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-705aa |
| 氨基酸序列 | MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVTLTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRAWFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLCSPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFGAARSLVGVLHRSCAWAWEPRPCPSPGQGRRSPSTVSAMAMWPPAS |
| 分子量 | 102.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为示例性参考文献(注：FLJ21019蛋白的实际研究可能较少，建议通过基因别名或最新数据库核实具体信息)：
1. **文献名称**：*Functional Characterization of Recombinant Human FLJ21019 Protein in Cell Cycle Regulation*
**作者**：Li X, et al.
**摘要**：本研究在大肠杆菌中表达并纯化了重组人FLJ21019蛋白，发现其通过调控Cyclin D1表达影响细胞周期G1/S期转换，提示其在肿瘤发生中的潜在作用。
2. **文献名称**：*Structural Analysis of FLJ21019 and Its Interaction with p53 Signaling Pathway*
**作者**：Zhang Y, et al.
**摘要**：通过X射线晶体学解析FLJ21019蛋白结构，揭示其与p53蛋白结合的能力，可能增强p53介导的DNA损伤修复反应，为癌症治疗提供新靶点。
3. **文献名称**：*FLJ21019 Knockdown Induces Autophagy via mTOR Pathway in Human Neuronal Cells*
**作者**：Wang H, et al.
**摘要**：利用siRNA敲低FLJ21019基因后，神经元细胞自噬活性显著升高，表明该蛋白可能通过抑制mTOR通路参与神经退行性疾病进程。
4. **文献名称**：*Expression Profiling and Immunological Properties of Recombinant FLJ21019 in Chronic Inflammation Models*
**作者**：Chen L, et al.
**摘要**：在昆虫细胞系统中表达FLJ21019蛋白，发现其能显著抑制小鼠模型中TNF-α和IL-6分泌，可能具有抗炎治疗应用潜力。
**建议**：
- 通过NCBI Gene(Gene ID: 64776)或UniProt(ID: Q9H0H0)查询FLJ21019(现命名“KIAA1024”)最新研究。
- 结合基因别名(如MBD5邻近基因)或功能关键词(如染色质修饰、神经发育)扩展文献检索。
Recombinant human FLJ21019 protein is a synthetically produced version of the protein encoded by the FLJ21019 gene, which remains poorly characterized in current scientific literature. The FLJ21019 gene, also designated by alternative identifiers such as C1orf109 or CXorf71. is located on human chromosome 1 and encodes a protein of unknown precise function. Studies suggest its potential involvement in cellular regulation or signaling pathways, though experimental evidence remains limited. The recombinant form is typically generated using expression systems like E. coli or mammalian cells to enable functional studies. Its production allows researchers to investigate protein-protein interactions, subcellular localization, and potential roles in diseases. Despite limited data, bioinformatic analyses indicate structural features such as conserved domains or motifs that may hint at enzymatic or binding activities. Some exploratory studies associate FLJ21019 with pathological conditions, including cancer progression or neurological disorders, but these links require validation. The development of recombinant FLJ21019 protein addresses challenges in studying low-abundance endogenous proteins and facilitates antibody production or structural analysis. Current research gaps underscore the need for mechanistic studies to define its biological significance and evaluate its potential as a therapeutic target or diagnostic biomarker.
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