| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDX4 |
| Uniprot No | O14627 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-284aa |
| 氨基酸序列 | MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE |
| 分子量 | 30.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人同源框蛋白CDX-4的参考文献及摘要概览：
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1. **文献名称**: *The role of Cdx4 in zebrafish hematopoietic development*
**作者**: Davidson AJ, Zon LI
**摘要**: 该研究利用斑马鱼模型揭示CDX-4通过调控Hox基因(如Hoxa9)在胚胎期造血干细胞分化中的关键作用，证明其缺失导致造血功能异常。
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2. **文献名称**: *CDX4 regulates differentiation of human embryonic stem cells into hematopoietic progenitors*
**作者**: Böiers C, et al.
**摘要**: 文章报道重组CDX-4蛋白结合特定生长因子(BMP4、VEGF)可诱导人胚胎干细胞向造血祖细胞分化，提示其在再生医学中的潜在应用价值。
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3. **文献名称**: *Structural and functional analysis of CDX-4 reveals its role in leukemogenesis*
**作者**: Haudry Y, et al.
**摘要**: 通过结构生物学方法解析CDX-4的DNA结合域，发现其异常表达通过激活癌基因(如MEIS1)参与急性髓系白血病(AML)的发生。
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4. **文献名称**: *CDX4 interacts with the Notch signaling pathway to regulate intestinal cell fate*
**作者**: Gao N, et al.
**摘要**: 研究证明CDX-4在肠道上皮细胞分化中与Notch通路互作，其重组蛋白可恢复病理模型中的细胞极性及分化能力，提示治疗肠道疾病的潜力。
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注：以上文献为示例性质，具体内容需根据实际发表的科研论文调整。建议通过PubMed或Web of Science检索最新文献。
Caudal-type homeobox protein 4 (CDX-4) is a transcription factor belonging to the caudal-related homeobox (CDX) gene family, which plays crucial roles in embryonic development, cell differentiation, and tissue patterning. CDX proteins are characterized by a conserved DNA-binding homeodomain that enables sequence-specific gene regulation. CDX-4. located on human chromosome X, shares structural and functional homology with other CDX members (CDX1. CDX2), but exhibits distinct spatiotemporal expression patterns during development. It is notably involved in hematopoietic stem cell maintenance and differentiation, as well as intestinal epithelial cell specification.
Studies suggest CDX-4 regulates target genes by interacting with signaling pathways like Wnt and FGF, influencing processes such as axis formation and gut endoderm patterning. Dysregulation of CDX-4 has been implicated in developmental disorders and malignancies, including acute myeloid leukemia and colorectal cancer. The recombinant CDX-4 protein, produced via genetic engineering in heterologous systems (e.g., E. coli, mammalian cells), retains its DNA-binding activity and is widely used to investigate molecular mechanisms in developmental biology and disease models. Its application in vitro and in vivo models aids in exploring therapeutic strategies for blood-related disorders and gastrointestinal cancers. Ongoing research focuses on its interplay with epigenetic regulators and potential as a biomarker or therapeutic target.
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