| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDS1 |
| Uniprot No | Q92903 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-98aa |
| 氨基酸序列 | MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMIS |
| 分子量 | 36.52 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人磷脂酸胞苷酰转移酶1(CDS1)蛋白的示例参考文献(均为虚构示例，仅用于说明格式)：
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1. **文献名称**: *Molecular characterization of human CDP-diacylglycerol synthase 1 (CDS1) and its role in phospholipid biosynthesis*
**作者**: Smith A, et al.
**摘要**: 该研究首次克隆并表征了人源CDS1的基因序列，发现其编码的酶催化磷脂酸(PA)转化为CDP-二酰基甘油(CDP-DAG)，并验证了其在酵母互补实验中的功能，揭示了CDS1在膜脂合成中的关键作用。
2. **文献名称**: *CDS1 deficiency disrupts mitochondrial function and causes cardiomyopathy in mice*
**作者**: Lee B, et al.
**摘要**: 通过构建CDS1基因敲除小鼠模型，发现CDS1缺失导致心肌细胞线粒体磷脂稳态异常，引发进行性心肌病，提示CDS1在心脏能量代谢中的重要性。
3. **文献名称**: *Regulation of CDS1 by growth signals: Implications for cell proliferation*
**作者**: Chen X, et al.
**摘要**: 发现CDS1的表达受EGF和MAPK信号通路调控，敲低CDS1会抑制细胞增殖，表明其通过调控磷脂代谢参与细胞生长信号转导。
4. **文献名称**: *Structural insights into the catalytic mechanism of human CDS1*
**作者**: Patel R, et al.
**摘要**: 通过X射线晶体学解析CDS1的三维结构，揭示其活性中心的关键氨基酸残基，并通过突变实验验证了酶催化机制，为靶向药物设计提供基础。
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**提示**：以上为虚构示例。如需真实文献，建议检索PubMed/Google Scholar，关键词：**"CDS1 protein", "CDP-diacylglycerol synthase 1", "phospholipid biosynthesis"**，并筛选近年的研究论文或经典综述。
CDP-diacylglycerol synthase 1 (CDS1) is a key enzyme in phospholipid biosynthesis, belonging to the CDS family of phosphatidyltransferases (EC 2.7.7.41). It catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), a critical phospholipid intermediate essential for producing major membrane components like phosphatidylinositol, phosphatidylglycerol, and cardiolipin. CDS1 is localized to the endoplasmic reticulum and mitochondrial-associated membranes, linking lipid metabolism with cellular membrane homeostasis. Its activity supports cellular processes including membrane biogenesis, signal transduction, and mitochondrial function.
The recombinant human CDS1 protein is engineered for research and potential therapeutic applications. Produced via heterologous expression systems (e.g., E. coli or mammalian cells), it retains enzymatic activity to study lipid pathways and disease mechanisms. CDS1 dysfunction is implicated in metabolic disorders, neurodegeneration, and cardiovascular diseases, as altered CDP-DAG levels disrupt lipid-dependent signaling and organelle dynamics. Recombinant CDS1 serves as a tool to explore phospholipid-driven processes, screen lipid metabolism regulators, and develop treatments for lipid-related pathologies. Structural studies using recombinant protein have also advanced understanding of its catalytic domains and regulatory mechanisms, highlighting its biotechnological and biomedical relevance.
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