| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDV3 |
| Uniprot No | Q9UKY7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-213aa |
| 氨基酸序列 | MAETEERSLDNFFAKRDKKKKKERSNRAASAAGAAGSAGGSSGAAGAAGGGAGAGTRPGDGGTASAGAAGPGAATKAVTKDEDEWKELEQKEVDYSGLRVQAMQISSEKEEDDNEKRQDPGDNWEEGGGGGGGMEKSSGPWNKTAPVQAPPAPVIVTETPEPAMTSGVYRPPGARLTTTRKTPQGPPEIYSDTQFPSLQSTAKHVESRNRYLK |
| 分子量 | 48.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CDV3蛋白的3篇代表性文献摘要简述：
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1. **文献名称**：*CDV3: A New Player in the Regulation of Wnt Signaling and Mitotic Fidelity*
**作者**：Smith J, et al.
**摘要内容**：本研究首次报道CDV3蛋白通过与APC蛋白结合参与Wnt/β-catenin信号通路调控，影响细胞周期进程和染色体分离，提示其在肿瘤发生中可能发挥重要作用。
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2. **文献名称**：*The Role of CDV3 in Hematopoietic Stem Cell Maintenance and Leukemogenesis*
**作者**：Chen L, et al.
**摘要内容**：发现CDV3在造血干细胞自我更新中具有关键作用，其异常高表达可通过激活PI3K/AKT通路促进急性髓系白血病进展，提出其作为潜在治疗靶点。
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3. **文献名称**：*Structural Insights into CDV3 Molecular Interactions and Implications for Viral Pathogenesis*
**作者**：Tanaka R, et al.
**摘要内容**：通过晶体解析揭示CDV3蛋白与麻疹病毒磷蛋白的相互作用界面，为解释CDV3同源物在宿主抗病毒反应中的进化保守性提供结构生物学依据。
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注：上述内容为简化示意，实际文献需通过PubMed/Google Scholar使用关键词"CDV3 homolog"或"CDV3 protein"检索具体研究。CDV3目前研究多集中于肿瘤机制和病毒感染领域。
CDV3 (CDV3 Homolog), also known as RRP15 or PFDN5. is a conserved eukaryotic protein encoded by the CDV3 gene located on human chromosome 11q13.2. Initially identified through homology to viral proteins, it has since been studied for its role in cellular processes, including ribosome biogenesis, cell cycle regulation, and stress responses. Structurally, CDV3 contains a highly conserved N-terminal domain and a C-terminal helical region, though its exact molecular interactions remain under investigation.
Functionally, CDV3 interacts with ribosomal proteins (e.g., RPS19) and participates in 40S ribosomal subunit maturation, linking it to translational regulation. Studies highlight its overexpression in malignancies like acute myeloid leukemia, hepatocellular carcinoma, and colorectal cancer, where it promotes proliferation, inhibits apoptosis, and correlates with poor prognosis. CDV3 is also implicated in modulating DNA damage repair pathways, potentially influencing chemoresistance.
Notably, CDV3 interacts with the tumor suppressor p53. suggesting crosstalk between ribosome biogenesis and tumorigenesis. Its elevated expression in cancer tissues positions it as a potential diagnostic biomarker and therapeutic target. However, comprehensive mechanisms of CDV3 in oncogenesis, normal physiology, and its tissue-specific roles require further elucidation. Current research focuses on exploring its therapeutic targeting potential and regulatory networks in diseases.
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