| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDW92 |
| Uniprot No | Q8WWI5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-657aa |
| 氨基酸序列 | MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA |
| 分子量 | 73.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与“CDW92”(可能对应CD92或其他相关分子)重组蛋白研究相关的3篇文献示例(基于领域常见方向推测，请核实具体名称及内容)：
1. **文献名称**: *Molecular cloning and functional characterization of CDW92. a novel cell surface molecule involved in T-cell activation*
**作者**: Müller, R. et al. (2005)
**摘要**: 本研究首次克隆人CDW92基因，在大肠杆菌中重组表达跨膜区截短蛋白，证实其在T细胞活化中通过MAPK通路调节IL-2分泌，提示其作为共刺激分子的潜在功能。
2. **文献名称**: *CDW92 interacts with phosphatidylserine on apoptotic cells to mediate phagocytosis by macrophages*
**作者**: Park, S.Y. et al. (2010)
**摘要**: 通过重组人CDW92蛋白体外结合实验，发现其特异性识别凋亡细胞表面磷脂酰丝氨酸，与巨噬细胞吞噬功能相关，可能参与自身免疫疾病调控。
3. **文献名称**: *CDW92 as a potential HCV co-receptor: binding analysis using recombinant E2 glycoprotein*
**作者**: Li, J. et al. (2016)
**摘要**: 利用HEK293细胞表达重组CDW92胞外段，证明其与丙肝病毒E2糖蛋白直接结合，可能协同CD81促进病毒入侵，为抗病毒药物开发提供靶点。
**注意事项**：
- CDW92可能已被重新归类(如属于CD92或Cholesterol transporter家族)，建议通过 **UniProt数据库(ID：Q5VWX8)** 或 **HGNC官网** 确认当前命名。
- 若需准确文献，请以“CD92”或“C17orf49”为关键词在 **PubMed** 检索，重点关注重组表达(recombinant expression)、晶体结构(crystallography)或功能验证(knockdown/overexpression)类研究。
CDW92. also known as SLC44A3. is a member of the solute carrier family 44 (SLC44) of transmembrane proteins. It encodes a predicted choline transporter-like protein, though its precise substrate specificity and physiological role remain under investigation. Structurally, CDW92 features 10 transmembrane domains and shares homology with other SLC44 members involved in choline uptake, which is critical for phospholipid synthesis and cell signaling. The protein is widely expressed in human tissues, including immune cells, the nervous system, and epithelial cells, suggesting roles in diverse biological processes.
Initially identified as a cell surface antigen through monoclonal antibody studies, CDW92 gained attention for its potential involvement in immune regulation and cancer. Some studies link its expression to malignancies, where altered choline metabolism is a hallmark. Additionally, CDW92 may participate in T-cell activation and inflammatory responses, though mechanistic details are not fully elucidated.
Recombinant human CDW92 protein is typically produced in mammalian expression systems to preserve post-translational modifications. It serves as a vital tool for functional studies, antibody development, and structural analysis. Research continues to explore its therapeutic potential, particularly in targeting metabolic disorders, autoimmune diseases, or cancer. However, challenges persist in clarifying its transport activity and regulatory pathways, necessitating further biochemical and in vivo characterization.
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