| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDON |
| Uniprot No | Q4KMG0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1287aa |
| 氨基酸序列 | MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPRET |
| 分子量 | 139 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CDON蛋白的3篇文献示例(基于模拟检索，供参考)：
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1. **标题**：*CDON regulates skeletal muscle development via Hedgehog signaling*
**作者**：Krauss, R.S., et al.
**摘要**：该研究通过重组人CDON蛋白实验，证明CDON作为SHH(Sonic Hedgehog)共受体，调控骨骼肌祖细胞分化和肌肉发育，揭示了其与Hedgehog通路的关键互作机制。
2. **标题**：*CDON functions as a tumor suppressor in colorectal cancer by modulating apoptosis*
**作者**：Bae, G.U., et al.
**摘要**：利用重组CDON蛋白的体外分析，发现其在结直肠癌细胞中诱导凋亡并抑制增殖，表明CDON可能通过结合p53依赖性通路发挥抑癌作用。
3. **标题**：*Structural characterization of the CDON extracellular domain reveals ligand-binding specificity*
**作者**：Zhang, X., et al.
**摘要**：通过重组表达CDON蛋白胞外域，解析其晶体结构，证实其与配体IHH(Indian Hedgehog)的特异性结合，为CDON在发育信号中的分子机制提供结构基础。
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**注**：以上文献为示例，实际文献需通过PubMed或Google Scholar以“CDON protein”“recombinant CDON”等关键词检索核实。建议选择近5-10年发表的高被引研究以获取最新成果。
CDON (Cell adhesion molecule-related/downregulated by oncogenes) is a cell surface receptor belonging to the immunoglobulin (Ig) superfamily. It plays critical roles in embryonic development, particularly in neurulation, myogenesis, and skeletal patterning. CDON acts as a co-receptor for the Hedgehog (Hh) signaling pathway, specifically interacting with Sonic Hedgehog (Shh) to regulate cell proliferation, differentiation, and tissue morphogenesis. Structurally, it contains multiple Ig-like domains and fibronectin type III repeats, facilitating cell-cell adhesion and signal transduction.
CDON’s involvement in development is underscored by its association with congenital disorders like holoprosencephaly when mutated. Interestingly, CDON expression is often downregulated in cancers, suggesting a potential tumor-suppressive role, though its oncogenic functions in certain contexts remain debated.
Recombinant human CDON protein, produced via engineered host systems (e.g., HEK293 cells), retains functional domains for studying interactions, signaling mechanisms, or therapeutic targeting. It serves as a tool to explore CDON’s dual roles in development and disease, including its interplay with pathways like Hh and Notch. Research leveraging recombinant CDON also aims to develop regenerative strategies or inhibitors for conditions linked to its dysregulation.
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