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Recombinant Human CDKL4 Protein

  • 中文名: 重组人周期素依赖性激酶样4(CDKL4)蛋白
  • 别    名: CDKL4Cyclin-dependent kinase-like 4; EC 2.7.11.22
货号: PA2000-6616
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点CDKL4
Uniprot NoQ5MAI5
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-315aa
氨基酸序列MEKYEKLAKT GEGSYGVVFK CRNKTSGQVV AVKKFVESED DPVVKKIALR EIRMLKQLKH PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVAD GVIKSVLWQT LQALNFCHIH NCIHRDIKPE NILITKQGII KICDFGFAQI LIPGDAYTDY VATRWYRAPE LLVGDTQYGS SVDIWAIGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFKS NGFFHGISIP EPEDMETLEE KFSDVHPVAL NFMKGCLKMN PDDRLTCSQL LESSYFDSFQ EAQIKRKARN EGRNRRRQQV LPLKS
分子量43.3 kDa
蛋白标签His tag N-Terminus
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下为假设的示例参考文献(仅供参考,实际文献需查阅数据库):

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1. **文献名称**: "Structural insights into CDKL4 kinase domain and its role in cell cycle regulation"

**作者**: Smith AB, et al.

**摘要**: 解析CDKL4激酶结构域晶体结构,揭示其与周期素结合的关键位点,证实其在G1/S期转化中的作用。

2. **文献名称**: "CDKL4 promotes tumorigenesis in triple-negative breast cancer via Wnt/β-catenin signaling"

**作者**: Chen L, Wang Y.

**摘要**: 发现CDKL4在三阴性乳腺癌中高表达,通过激活Wnt通路促进肿瘤细胞增殖和侵袭。

3. **文献名称**: "CDKL4 deficiency impairs neuronal development and synaptic plasticity"

**作者**: Tanaka K, et al.

**摘要**: 研究CDKL4敲除小鼠模型,表明CDKL4缺失导致海马神经元突触可塑性异常及认知缺陷。

4. **文献名称**: "Pharmacological inhibition of CDKL4 sensitizes colorectal cancer to chemotherapy"

**作者**: Johnson R, et al.

**摘要**: 开发CDKL4小分子抑制剂,证明其可增强结直肠癌细胞对5-FU的化疗敏感性,提示潜在治疗靶点。

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注:以上内容为模拟示例,实际研究需通过PubMed、Google Scholar等平台搜索关键词 **"CDKL4 protein function"** 或 **"CDKL4 in cancer/neurology"** 获取真实文献。


背景信息

Cyclin-dependent kinase-like 4 (CDKL4) is a member of the CDK family of serine/threonine kinases, which are critical regulators of cell cycle progression and transcriptional modulation. While its precise biological functions remain less characterized compared to other CDK members, CDKL4 shares structural homology with CDKL5. a kinase implicated in neurodevelopmental disorders. CDKL4 is encoded by the *CDKL4* gene located on human chromosome Xp22.13 and is highly expressed in tissues such as the brain, testis, and certain cancers.

Emerging evidence suggests CDKL4 may play roles in cell proliferation, differentiation, and neuronal development, potentially through phosphorylation-mediated signaling cascades. In vitro studies indicate its kinase activity can influence transcriptional regulation by interacting with RNA-binding proteins or chromatin modifiers. Dysregulation of CDKL4 has been loosely associated with cancer progression, particularly in gliomas and breast cancers, though mechanistic insights remain limited.

Recombinant human CDKL4 protein, produced via bacterial or mammalian expression systems, is widely used to study its biochemical properties, substrate specificity, and interaction networks. Structural analyses reveal a conserved kinase domain with unique insert regions, distinguishing it from canonical CDKs. Ongoing research aims to elucidate its physiological substrates, regulatory pathways, and potential therapeutic relevance in cancers or neurological disorders. The development of selective CDKL4 inhibitors could offer novel strategies for targeting CDKL4-driven pathologies.


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