| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC24 |
| Uniprot No | Q8N4L8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-307aa |
| 氨基酸序列 | MLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLSLELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDLPEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLRGLLEEECHTLEREILILQRCLEEEYLRPCHPSEAALEPTLAELKEQKKAMEQELQASVGPSCVSPNHRQRPLGSSTQGLRPPLPLCGVAPLQCCLPAPPLEPYLRPRGQSATHRWGRQLQCSPREGPASTPMSSAAPQAPA |
| 分子量 | 60.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC24的虚构参考文献示例(仅供参考，实际文献需查询数据库)：
1. **"CCDC24 regulates sperm motility through interaction with flagellar components"**
*Authors: Li X, Chen Y, Wang J*
摘要：本研究通过基因敲除模型发现，CCDC24在小鼠精子鞭毛结构中高表达，其缺失导致精子运动能力下降。蛋白质组学分析表明CCDC24与动力蛋白复合物相互作用，暗示其在鞭毛组装中的关键作用。
2. **"Genomic analysis of CCDC24 reveals associations with primary ciliary dyskinesia"**
*Authors: Smith AR, Johnson B, García-Sánchez R*
摘要：通过对原发性纤毛运动障碍患者的全基因组测序，发现CCDC24基因突变与纤毛结构异常相关。体外实验证实突变型CCDC24导致纤毛搏动频率降低，提示其参与纤毛功能调控。
3. **"CCDC24 overexpression in breast cancer correlates with tumor metastasis"**
*Authors: Tanaka K, Müller S*
摘要：该研究通过癌症组织芯片分析发现，CCDC24在转移性乳腺癌中显著高表达。体外实验表明其过表达通过激活MAPK通路促进细胞迁移，提示其可能作为癌症进展的生物标志物。
4. **"Structural characterization of the coiled-coil domain in CCDC24"**
*Authors: Zhang L, Gupta P, Wu H*
摘要：利用X射线晶体学解析CCDC24卷曲螺旋结构域的三维结构，揭示其独特的二聚化界面。分子动力学模拟表明该结构域可能参与介导与其他细胞骨架蛋白的相互作用。
注：以上内容为模拟生成，实际研究需查阅真实文献数据库(如PubMed)。
Coiled-coil domain-containing protein 24 (CCDC24) is a poorly characterized protein belonging to the CCDC family, which is defined by the presence of conserved coiled-coil structural motifs. These motifs mediate protein-protein interactions, suggesting CCDC24's potential involvement in cellular processes such as cytoskeletal organization, intracellular trafficking, or signal transduction. While the precise biological function of CCDC24 remains unclear, studies indicate its expression in various tissues, with higher levels observed in the testes, suggesting a possible role in male reproductive biology.
Emerging evidence links CCDC24 to human diseases. For instance, mutations in the CCDC24 gene have been implicated in asthenozoospermia, a condition marked by reduced sperm motility and male infertility. Structural analyses predict that pathogenic variants may disrupt its coiled-coil domains, potentially affecting interactions with proteins involved in sperm flagellar structure or energy metabolism. Additionally, CCDC24 overexpression has been detected in certain cancers, including prostate and breast cancer, though its oncogenic mechanisms remain underexplored.
Despite these associations, mechanistic insights into CCDC24's molecular functions are limited. Current research focuses on identifying its binding partners, subcellular localization, and regulatory pathways. Animal models and in vitro studies are needed to elucidate its contribution to cellular dynamics and disease pathogenesis. Further characterization of CCDC24 could reveal novel therapeutic targets for infertility or cancer.
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