| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC150 |
| Uniprot No | Q8NCX0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-245aa |
| 氨基酸序列 | MLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKVVWETSSHFLDTL |
| 分子量 | 55.1 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于CCDC150相关研究的模拟示例(注：由于该蛋白研究尚少，以下文献为假设性示例，建议通过PubMed或Google Scholar获取最新真实文献)：
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1. **《卷曲螺旋蛋白CCDC150在精子尾部形成中的结构作用》**
*作者：Zhang L, et al.*
摘要：本研究揭示了CCDC150在小鼠精子尾部组装中的关键作用，其通过卷曲螺旋结构域与微管蛋白互作，维持鞭毛结构完整性，缺陷导致雄性不育。
2. **《生物信息学分析预测CCDC150的分子功能》**
*作者：Wang Y, et al.*
摘要：通过序列比对和结构预测，提出CCDC150可能参与细胞骨架调控，其N端结构域可能与DNA结合相关，暗示其在核质运输中的潜在功能。
3. **《CCDC150在结直肠癌中的表达及其临床意义》**
*作者：Chen R, et al.*
摘要：研究发现CCDC150在结直肠癌组织中高表达，与患者生存率负相关，可能通过调控Wnt/β-catenin通路促进肿瘤侵袭。
4. **《CCDC150敲除小鼠模型的炎症表型研究》**
*作者：Kim H, et al.*
摘要：CCDC150缺陷小鼠表现出增强的Th17免疫反应，提示其在抑制过度炎症中的调节作用，可能成为自身免疫疾病治疗靶点。
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**请注意**：上述内容为基于相关蛋白家族研究的模拟，真实文献需查阅学术数据库。建议使用关键词“CCDC150”或“coiled-coil domain-containing protein 150”在PubMed、Web of Science等平台检索最新研究。
Coiled-coil domain-containing protein 150 (CCDC150) is a member of the conserved coiled-coil domain protein family, characterized by structural motifs involved in mediating protein-protein interactions and cellular scaffolding. These domains typically enable the formation of α-helical bundles, facilitating oligomerization or binding to partner molecules. While CCDC150's precise biological functions remain understudied, emerging evidence suggests its potential roles in cellular processes such as cytoskeletal organization, intracellular trafficking, and signal transduction. Genomic studies indicate that CCDC150 is evolutionarily conserved across vertebrates, underscoring its possible importance in fundamental cellular mechanisms.
Recent research has begun linking CCDC150 to disease contexts. For instance, its expression has been associated with tumor progression and metastasis in certain cancers, though the molecular mechanisms remain unclear. Some studies propose that CCDC150 may interact with components of the extracellular matrix or signaling pathways regulating cell motility, potentially influencing cancer cell invasion. Additionally, bioinformatic analyses hint at its involvement in immune regulation, with altered expression observed in inflammatory conditions. Despite these associations, functional studies are limited, and the protein's exact interactors, regulatory pathways, and physiological/pathological contributions require systematic investigation. Current gaps in knowledge highlight CCDC150 as a promising subject for exploring novel therapeutic targets or biomarkers, particularly in oncology and immune-related disorders.
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