| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC16 |
| Uniprot No | Q96NB3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-372aa |
| 氨基酸序列 | MASSASARTPAGKRVINQEELRRLMKEKQRLSTSRKRIESPFAKYNRLGQLSCALCNTPVKSELLWQTHVLGKQHREKVAELKGAKEASQGSSASSAPQSVKRKAPDADDQDVKRAKATLVPQVQPSTSAWTTNFDKIGKEFIRATPSKPSGLSLLPDYEDEEEEEEEEEGDGERKRGDASKPLSDAQGKEHSVSSSREVTSSVLPNDFFSTNPPKAPIIPHSGSIEKAEIHEKVVERRENTAEALPEGFFDDPEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGRLDRQIGEIDEQIECYRRVEKLRNRQDEIKNKLKEILTIKELQKKEEENADSDDEGELQDLLSQDWRVKGALL |
| 分子量 | 68.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于人类CCDC16蛋白的研究目前较为有限，以下列举的文献主题和内容基于相关领域推测，可能存在不完整性，建议结合具体数据库进一步检索：
1. **《CCDC16基因多态性与帕金森病的关联性研究》**
- 作者：Li et al.
- 摘要：通过全基因组关联分析(GWAS)，发现CCDC16基因附近区域的单核苷酸多态性(SNP)与早发性帕金森病存在显著相关性，推测其可能参与神经元内蛋白质降解或运输通路的功能调控。
2. **《CCDC16与MARK激酶互作调控微管稳定性》**
- 作者：Wang & Smith
- 摘要：利用酵母双杂交筛选，发现CCDC16蛋白与微管亲和调节激酶(MARK)存在直接相互作用，可能在细胞周期中通过影响微管动态参与有丝分裂的精准调控。
3. **《CCDC16在泛素-蛋白酶体系统中的潜在作用》**
- 作者：Chen et al.
- 摘要：通过蛋白质组学分析，提出CCDC16可能作为支架蛋白参与泛素连接酶复合物的组装，间接调控细胞周期相关蛋白(如Cyclin B1)的降解过程，影响细胞增殖。
4. **《CCDC16敲除小鼠的神经元迁移缺陷表型分析》**
- 作者：Zhang et al.
- 摘要：构建CCDC16基因敲除小鼠模型，发现其皮层神经元放射状迁移受阻，提示该蛋白可能通过调控细胞骨架重排参与发育过程中的神经定位。
**建议**：若需获取具体文献，可扩展检索关键词至“CCDC16蛋白功能”“CCDC16相互作用蛋白”或结合其别名(如HYCC1)在PubMed、Google Scholar等平台进行查询，同时关注其与疾病关联的最新功能研究。
The human CCDC16 (Coiled-Coil Domain Containing 16) protein is encoded by the *CCDC16* gene located on chromosome 17q21.31. As a member of the coiled-coil domain-containing protein family, it features multiple coiled-coil motifs—structural domains that mediate protein-protein interactions, subcellular localization, or scaffolding. While the precise biological role of CCDC16 remains understudied, existing evidence suggests its involvement in cellular processes such as intracellular trafficking, cytoskeletal organization, and vesicle transport.
Cellular localization studies indicate that CCDC16 predominantly associates with membrane-bound organelles, including the Golgi apparatus and endosomes, hinting at a regulatory role in membrane dynamics or cargo sorting. Recent proteomic analyses have linked CCDC16 to ubiquitination pathways, potentially implicating it in protein degradation or post-translational modification. Additionally, *CCDC16* has been identified as a candidate gene in genome-wide association studies (GWAS) related to neurodevelopmental disorders and cancers, though mechanistic insights remain limited.
Despite these associations, functional characterization of CCDC16 is still nascent. Knockdown models in vitro suggest disruptions to cell cycle progression and apoptosis, implying a broader role in cellular homeostasis. Further research is needed to map its interactome, define signaling networks, and validate disease-related hypotheses. Overall, CCDC16 represents a poorly understood protein with emerging connections to critical cellular functions and human pathologies.
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