| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC110 |
| Uniprot No | Q8TBZ0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-833aa |
| 氨基酸序列 | MSPEKQHREEDEVDSVLLSASKILNSSEGVKESGCSDTEYGCIAESENQIQPQSALKVLQQQLESFQALRMQTLQNVSMVQSEISEILNKSIIEVENPQFSSEKNLVFGTRIEKDLPTENQEENLSMEKSHHFEDSKTLHSVEEKLSGDSVNSLPQSVNVPSQIHSEDTLTLRTSTDNLSSNIIIHPSENSDILKNYNNFYRFLPTAPPNVMSQADTVILDKSKITVPFLKHGFCENLDDICHSIKQMKEELQKSHDGEVALTNELQTLQTDPDVHRNGKYDMSPIHQDKMNFIKEENLDGNLNEDIKSKRISELEALVKKLLPFRETVSKFHVHFCRKCKKLSKSEMHRGKKNEKNNKEIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFTTQSLIQKVETYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTHQLLKEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKDEKLNLETTLQESTAARQIMEREIENIQTYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENSISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTYISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKDRTLKHH |
| 分子量 | 123.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC110的参考文献及简要摘要(基于公开信息模拟，非真实文献)：
1. **"CCDC110 promotes breast cancer cell migration via EMT regulation"**
- 作者：Smith A, et al.
- 摘要：研究发现CCDC110通过激活上皮-间充质转化(EMT)相关通路(如TGF-β)，增强乳腺癌细胞迁移和侵袭能力，提示其作为转移治疗的潜在靶点。
2. **"High CCDC110 expression correlates with poor prognosis in ovarian cancer"**
- 作者：Wang L, et al.
- 摘要：通过对卵巢癌组织样本分析，发现CCDC110的高表达与患者总生存期缩短显著相关，可能通过调控细胞周期蛋白促进肿瘤增殖。
3. **"CCDC110 interacts with Wnt/β-catenin signaling in colorectal cancer"**
- 作者：Kim S, et al.
- 摘要：揭示了CCDC110与Wnt/β-catenin通路的相互作用，通过稳定β-catenin蛋白促进结直肠癌细胞增殖和耐药性。
4. **"Functional analysis of CCDC110 knockout in hepatocellular carcinoma"**
- 作者：Zhang Y, et al.
- 摘要：利用CRISPR技术敲除CCDC110.发现其缺失显著抑制肝癌细胞增殖并诱导凋亡，表明其在肝癌发生中的关键作用。
注：以上文献为模拟示例，实际研究需通过学术数据库(如PubMed、Web of Science)检索最新成果。
Coiled-coil domain-containing protein 110 (CCDC110) is a relatively understudied member of the CCDC family, characterized by the presence of coiled-coil structural motifs that mediate protein-protein interactions. These motifs, formed by alpha-helices winding around each other, enable CCDC110 to participate in diverse cellular processes, including structural organization, signaling, and intracellular trafficking. While its exact biological functions remain unclear, emerging studies suggest potential roles in cilia-related pathways or cytoskeletal dynamics, as other CCDC proteins are known to influence ciliary assembly, cell motility, and organelle positioning.
CCDC110 is encoded by the *CCDC110* gene located on human chromosome 2 (2q31.1). Although its expression pattern and regulation are not fully mapped, transcriptomic data indicate broad tissue distribution, with notable presence in reproductive and secretory tissues. Recent proteomic analyses have linked CCDC110 to protein networks involved in cell division and membrane trafficking, hinting at possible contributions to cellular proliferation or polarization. Mutations or dysregulation in CCDC genes are often associated with ciliopathies, cancers, or developmental disorders, but direct disease connections for CCDC110 remain speculative. Current research focuses on elucidating its interactome, post-translational modifications, and functional validation in model systems to clarify its physiological and pathological relevance. Further investigations are needed to define its molecular mechanisms and therapeutic potential.
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