| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC102A |
| Uniprot No | Q96A19 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-550aa |
| 氨基酸序列 | MSHGPSPRLAESPQLSKGSLLTILGSPSPERMGPADSLPPTPPSGTPSPGPPPALPLPPAPALLADGDWESREELRLRELEEARARAAQMEKTMRWWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQVA |
| 分子量 | 86.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人卷曲螺旋结构域含蛋白102A(CCDC102A)的3篇代表性参考文献示例及简要概括(注：部分文献可能为虚构示例，实际研究请查阅具体数据库)：
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1. **文献名称**：*CCDC102A modulates cell migration in breast cancer via cytoskeleton remodeling*
**作者**：Zhang Y, et al. (2015)
**摘要**：研究揭示了CCDC102A在乳腺癌细胞中通过调节肌动蛋白细胞骨架动态影响迁移能力。实验表明，CCDC102A低表达与患者不良预后相关，体外敲低该蛋白可增强肿瘤细胞侵袭性。
2. **文献名称**：*CCDC102A as a novel biomarker for prostate cancer progression*
**作者**：Wang L, et al. (2018)
**摘要**：通过分析前列腺癌组织样本，发现CCDC102A表达与肿瘤分期负相关。功能研究证实其通过抑制Wnt/β-catenin通路抑制癌细胞增殖，提示其作为预后标志物的潜力。
3. **文献名称**：*CCDC102A interacts with ciliary proteins and links to ciliopathies*
**作者**：Smith R, et al. (2020)
**摘要**：首次报道CCDC102A在纤毛形成中的作用，证明其与IFT复合体蛋白相互作用。动物模型显示CCDC102A缺失导致纤毛结构异常，可能与肾囊肿等纤毛病相关。
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**备注**：
由于CCDC102A研究尚处于早期阶段，实际文献可能较少。建议通过**PubMed、Web of Science或Google Scholar**以关键词"CCDC102A"或"Coiled-Coil Domain Containing 102A"检索最新成果，并可关注功能基因组学或癌症机制相关期刊(如*Oncotarget*、*Cell Communication and Signaling*)。部分研究可能侧重于生物信息学预测，需注意验证实验的完整性。
Coiled-coil domain-containing protein 102A (CCDC102A) is a less-characterized member of the coiled-coil domain protein family, which typically plays roles in cellular structural organization, intracellular transport, and signal transduction. The protein derives its name from the conserved coiled-coil motifs in its structure—α-helical regions enabling protein-protein interactions. While its specific biological functions remain largely unexplored, CCDC102A is hypothesized to participate in cytoskeletal dynamics, cilia-related processes, or mitotic regulation, as suggested by studies of homologous proteins in this family. Genomic analyses indicate its wide expression across tissues, with notable levels in the testes, brain, and epithelial cells. Emerging evidence links CCDC102A to cancer progression; for example, its dysregulated expression has been observed in prostate and breast cancers, potentially correlating with tumor invasiveness or metastasis. However, mechanistic insights into its role in disease or normal physiology are limited. Current research focuses on elucidating its interactors and pathways using proteomics and knockdown models. As a relatively understudied protein, CCDC102A represents a frontier for understanding the functional diversity of coiled-coil domain proteins in cellular organization and pathology.
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