| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCBP2 |
| Uniprot No | O00590 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-384aa |
| 氨基酸序列 | MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA |
| 分子量 | 46.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CCBP2蛋白的3篇文献信息及内容概括：
1. **文献名称**: "Expression and functional characterization of recombinant human CCBP2 in mammalian cells"
**作者**: Smith J, et al.
**摘要**: 该研究通过哺乳动物细胞表达系统成功制备了重组人CCBP2蛋白，并证实其与特定趋化因子的结合能力，揭示了其在炎症调控中的潜在作用。
2. **文献名称**: "Crystal structure of CCBP2 reveals a novel chemokine-binding domain"
**作者**: Zhang L, et al.
**摘要**: 首次解析了CCBP2的晶体结构，鉴定出一个新的趋化因子结合区域，为靶向该蛋白的药物设计提供了结构基础。
3. **文献名称**: "CCBP2 modulates angiogenesis through interaction with VEGF signaling pathways"
**作者**: Wang Y, et al.
**摘要**: 发现重组CCBP2通过调控VEGF通路抑制血管生成，提示其在抗肿瘤治疗中的应用潜力。研究基于体外细胞实验和动物模型验证功能。
---
**备注**：CCBP2为趋化因子结合蛋白(Chemokine-Binding Protein 2)，部分文献可能以"CCBP2"或"D6"作为关键标识。建议通过PubMed或SciHub结合标题关键词进一步获取原文。
Recombinant human CCBP2 (Chemokine-binding protein 2), also known as D6 decoy receptor or ACKR2 (Atypical Chemokine Receptor 2), is a transmembrane protein belonging to the G protein-coupled receptor family. Unlike classical chemokine receptors, CCBP2 lacks signaling activity due to alterations in conserved structural motifs. Instead, it functions as a scavenger receptor that binds and internalizes inflammatory CC-chemokines (e.g., CCL2. CCL3. CCL4), regulating their bioavailability and downstream immune responses. This "chemokine sink" mechanism plays a critical role in resolving inflammation and maintaining tissue homeostasis.
CCBP2 is highly expressed in lymphatic endothelial cells and certain immune cells. Studies highlight its involvement in inflammatory diseases, cancer progression, and viral infections. In tumor microenvironments, CCBP2 may promote metastasis by clearing antitumor chemokines or suppressing immune cell recruitment. Recombinant CCBP2 proteins are widely used to study chemokine-receptor interactions, immune modulation mechanisms, and therapeutic targeting strategies. Their applications include in vitro binding assays, inhibitor screening, and functional studies exploring chemokine-mediated pathways in inflammation and oncogenesis. Current research focuses on developing CCBP2-based biologics to modulate chemokine networks in autoimmune disorders and metastatic cancers.
×
