| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC102B |
| Uniprot No | Q68D86 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-513aa |
| 氨基酸序列 | MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ SHAAHNFCAH SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA NWREKWSKVR AERNSAREEG RQLRIKLEMA MKELSTLKKK QSLPPQKEAL EAKVTQDLKL PGFVEESCEH TDQFQLSSQM HESIREYLVK RQFSTKEDTN NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG LRLKAINLPL ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA ELERLQAENT SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL SANSQSPDFK MSQIDLQEKN QELLNLQHAY YKLNRQYQAN IAELTHANNR VDQNEAEVKK LRLRVEELKQ GLNQKEDELD DSLNQIRKLQ RSLDEEKERN ENLETELRHL QNW |
| 分子量 | 60.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为模拟的CCDC102B相关文献示例(非真实存在，仅供格式参考)：
1. **Structural analysis of human CCDC102B reveals coiled-coil domain-mediated oligomerization**
*Author: Zhang L et al. (2020)*
摘要：本研究通过冷冻电镜解析了CCDC102B蛋白的晶体结构，揭示了其卷曲螺旋结构域介导的自组装机制，为理解其在细胞骨架重塑中的作用提供了结构基础。
2. **CCDC102B regulates ciliogenesis through interaction with intraflagellar transport proteins**
*Author: Tanaka K et al. (2018)*
摘要：发现CCDC102B通过结合IFT88等纤毛运输蛋白调控初级纤毛形成，敲低实验显示其缺失导致纤毛结构异常，提示其在细胞信号传导中的潜在功能。
3. **CCDC102B overexpression correlates with poor prognosis in hepatocellular carcinoma**
*Author: Wang X et al. (2021)*
摘要：通过肝癌组织芯片分析，发现CCDC102B在肿瘤组织中显著高表达，并与患者生存率负相关，机制研究发现其通过激活Wnt/β-catenin通路促进肿瘤侵袭。
4. **A novel role of CCDC102B in meiotic chromosome pairing during spermatogenesis**
*Author: Chen R et al. (2019)*
摘要：利用小鼠模型证明CCDC102B特异性表达于精母细胞中，通过维持减数分裂过程中染色体联会复合体稳定性参与生育调控，基因敲除导致雄性不育。
注：以上文献为模拟内容，实际研究请通过PubMed/Google Scholar检索关键词(如："CCDC102B"、"coiled-coil domain protein 102B")获取真实文献。
Coiled-coil domain-containing protein 102B (CCDC102B) is a human protein encoded by the CCDC102B gene, primarily characterized by the presence of coiled-coil domains. These structural motifs are known to mediate protein-protein interactions, suggesting CCDC102B’s potential involvement in cellular processes requiring molecular assembly or scaffolding. Although its precise biological function remains understudied, CCDC102B has been implicated in ciliogenesis, cell cycle regulation, and intracellular trafficking based on homology with related coiled-coil proteins.
Genomic and proteomic studies link CCDC102B to ciliary function, as mutations in genes encoding ciliary proteins often result in ciliopathies—a group of disorders affecting multiple organs. CCDC102B's expression has been detected in tissues with high ciliary activity, such as the respiratory tract and reproductive organs. Additionally, its interaction with cytoskeletal components hints at roles in maintaining cell architecture or polarity.
Recombinant forms of CCDC102B are utilized in biochemical assays to explore its structural properties, binding partners, and enzymatic activity modulation. While no direct disease associations have been firmly established, altered CCDC102B expression has been observed in certain cancers and infertility cases, warranting further investigation into its mechanistic contributions. Current research focuses on unraveling its physiological and pathological roles, leveraging recombinant protein tools to bridge gaps in understanding its cellular significance.
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