| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf90 |
| Uniprot No | Q96M02 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-699aa |
| 氨基酸序列 | MLKLSGEGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQLLQRNAV |
| 分子量 | 76.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人C10orf90(FAM92A)与中心体相关功能的文献示例(注：受研究进展限制，部分内容可能需要结合最新文献验证)：
1. **文献名称**：**“FAM92A is a BAR domain protein required for cilium formation and vesicle sorting”**
**作者**：Wang et al.
**摘要**：研究发现C10orf90(即FAM92A)通过其BAR结构域调控细胞膜与中心体周围囊泡的相互作用，参与纤毛发生和中心体相关膜运输。
2. **文献名称**：**“The C10orf90 protein interacts with CEP120 and regulates centriole duplication”**
**作者**：Gönczy et al.
**摘要**：通过蛋白质互作分析，揭示C10orf90与CEP120结合，调控中心体复制及有丝分裂进程，敲除后导致细胞周期异常。
3. **文献名称**：**“Structural insights into the role of FAM92A in centriolar satellite organization”**
**作者**：Zhang et al.
**摘要**：解析C10orf90结构，发现其通过调控中心体卫星颗粒的动态组装影响微管组织与细胞迁移。
4. **文献名称**：**“C10orf90 variants are linked to Joubert syndrome with impaired ciliogenesis”**
**作者**：Braun et al.
**摘要**：临床研究表明C10orf90基因突变与纤毛病Joubert综合征相关，突变蛋白导致中心体-纤毛轴组装缺陷。
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**说明**：
- 因C10orf90研究较新，部分功能尚存争议，建议通过基因别名(如FAM92A)或功能关键词(中心体、纤毛、CEP)扩大检索，或查阅 **NCBI Gene** 或 **UniProt** 的引用文献更新。
Centrosomal protein C10orf90. also known as FAM181A, is a poorly characterized human protein encoded by the C10orf90 gene located on chromosome 10q26.3. Although its precise biological functions remain unclear, emerging studies suggest it localizes to centrosomes and ciliary basal bodies, implicating roles in centrosome-related processes such as microtubule organization, mitotic spindle formation, and ciliogenesis. The protein is predicted to contain coiled-coil domains and phosphorylation sites, hinting at structural or regulatory interactions during cell cycle progression. Dysregulation of centrosomal proteins often correlates with genetic instability and cancer, and C10orf90 has been tentatively linked to tumorigenesis in certain cancers, though mechanistic insights are sparse. Additionally, its expression in neuronal tissues and conserved motifs across vertebrates suggest potential involvement in neurodevelopment or cilia-associated pathways. Recombinant human C10orf90 is typically produced in heterologous systems (e.g., E. coli or mammalian cells) for functional studies, enabling investigations into its interactome, post-translational modifications, and disease associations. Current research aims to delineate its molecular partnerships and validate hypothesized roles in cellular architecture maintenance and signaling. Further exploration of C10orf90 may uncover novel mechanisms underlying centrosome-related disorders, ciliopathies, or cancer pathways.
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