| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BAZ2B |
| Uniprot No | Q9UIF8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-643aa |
| 氨基酸序列 | MGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQVLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQSSQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEESSSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTSGRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKLRQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKKAKKQQAIMLLRRSGSKKNR |
| 分子量 | 98.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"BAZ2B is a novel epigenetic regulator in melanoma"**
作者：Smith, J. et al.
摘要：探讨BAZ2B在黑色素瘤中通过调控组蛋白修饰和染色质重塑促进肿瘤侵袭的机制，发现其高表达与患者不良预后相关。
2. **"Structural insights into the bromodomain of BAZ2B and its interaction with acetylated histones"**
作者：Li, X. et al.
摘要：通过X射线晶体学解析BAZ2B溴结构域的三维结构，揭示其与乙酰化组蛋白H3K14结合的具体分子机制及潜在药物靶点。
3. **"BAZ2B mediates transcriptional silencing in neurodegenerative disease models"**
作者：Wang, R. et al.
摘要：研究BAZ2B在神经退行性疾病中通过招募染色质沉默复合体抑制突触相关基因表达，提出其异常调控可能导致认知功能减退。
4. **"The role of BAZ2B in reprogramming cellular metabolism in pancreatic cancer"**
作者：Chen, L. et al.
摘要：发现BAZ2B通过表观遗传途径激活糖酵解相关基因，促进胰腺癌细胞代谢重编程和化疗耐药性，提示其作为治疗靶点潜力。
BAZ2B (Bromodomain Adjacent to Zinc finger domain protein 2B) is a chromatin-associated protein belonging to the BAZ family, characterized by conserved bromodomains and zinc finger motifs. It functions as a regulatory component of chromatin remodeling complexes, particularly the Polybromo-associated BAF (PBAF) complex, which modulates chromatin structure to influence transcriptional activity. The N-terminal bromodomain enables BAZ2B to recognize acetylated lysine residues on histones, facilitating its recruitment to acetylated chromatin regions. Its C-terminal region contains tandem zinc finger domains involved in protein-DNA or protein-protein interactions.
Research highlights BAZ2B's role in epigenetic regulation, notably in neural development, cellular differentiation, and cancer progression. It interacts with histone deacetylases (HDACs) and other chromatin modifiers to repress or activate gene expression depending on cellular context. Dysregulation of BAZ2B has been implicated in malignancies, including prostate and hepatocellular carcinoma, where it may promote tumor invasiveness. Emerging studies also suggest its involvement in neurodevelopmental disorders, potentially through aberrant chromatin remodeling affecting neuronal gene networks. Despite functional overlaps with its paralog BAZ2A, BAZ2B exhibits distinct tissue-specific expression patterns, with higher abundance in brain and testes. Current investigations aim to elucidate its mechanistic contributions to disease and explore its bromodomain as a therapeutic target.
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