| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BAT4 |
| Uniprot No | Q9HBU1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-356aa |
| 氨基酸序列 | MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSLSQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRSAPQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF |
| 分子量 | 65.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人同源框蛋白BarH样1(BARX1)的3-4篇文献的示例性列举(均为虚构，仅供参考)：
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1. **文献名称**：*BARX1 Regulates Odontogenic Differentiation in Dental Mesenchyme*
**作者**：Kim S, et al.
**摘要**：研究发现BARX1在小鼠牙齿发育中通过调控MSX1和BMP4的表达，影响牙乳头间充质细胞的分化，敲除BARX1导致牙釉质及牙本质形成缺陷，提示其在牙齿形态发生中的关键作用。
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2. **文献名称**：*Epigenetic Silencing of BARX1 Correlates with Gastric Cancer Metastasis*
**作者**：Takahashi M, et al.
**摘要**：通过分析胃癌组织样本，发现BARX1启动子高甲基化导致其表达下调，与肿瘤侵袭性和预后不良相关;体外实验表明BARX1过表达可抑制EMT过程，揭示其作为抑癌基因的潜在机制。
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3. **文献名称**：*BARX1 in Enteric Nervous System Development*
**作者**：Zhang Y, et al.
**摘要**：研究表明BARX1通过调控Wnt/β-catenin信号通路，促进肠道神经嵴细胞的迁移和分化，缺失BARX1的小鼠出现肠道神经节发育异常，为肠神经病变提供分子机制解释。
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4. **文献名称**：*BARX1 and CDX2 Interaction in Colorectal Homeostasis*
**作者**：Qin H, et al.
**摘要**：BARX1与CDX2在结肠上皮中呈现拮抗表达模式，BARX1抑制CDX2的转录活性，影响肠道细胞命运决定;该互作可能参与结直肠癌中上皮-间质转化的调控。
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**注**：以上文献及摘要均为示例性虚构，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
BarH-like homeobox 1 (BARX1) is a member of the Bar subclass of homeodomain-containing transcription factors that play critical roles in embryonic development, particularly in organogenesis, cell differentiation, and tissue patterning. Initially identified through homology to the *BarH* genes in *Drosophila*, BARX1 is evolutionarily conserved and regulates gene expression networks by binding to specific DNA sequences. It is prominently involved in the development of the digestive system, craniofacial structures, and teeth. During embryogenesis, BARX1 is expressed in mesenchymal cells of the stomach, where it influences epithelial differentiation and gastric gland formation. It also contributes to mandibular and dental patterning by interacting with signaling pathways like Wnt and BMP.
Beyond development, BARX1 has implications in disease. Dysregulation of BARX1 is associated with congenital anomalies, including Hirschsprung's disease, dental agenesis, and craniofacial malformations. Its aberrant expression has also been linked to cancers, such as ovarian and hepatocellular carcinomas, where it may act as a tumor suppressor or context-dependent oncogene. Recombinant BARX1 protein, generated via genetic engineering, is utilized in vitro to study its molecular interactions, regulatory mechanisms, and therapeutic potential. Research on BARX1 continues to uncover its multifaceted roles in health and disease, offering insights into regenerative medicine and targeted therapies.
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