| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BAZ1A |
| Uniprot No | Q9NRL2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1457-1556aa |
| 氨基酸序列 | LVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPSNVDQVSTPPAAKKSRI |
| 分子量 | 36.74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于BAZ指蛋白BAZ1A的3篇文献摘要示例(部分内容基于现有研究推测整合)：
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1. **文献名称**：*"The chromatin remodeler ACF1 regulates H3K9 acetylation via BAZ1A-mediated histone binding"*
**作者**：Smith, J. et al. (2020)
**摘要**：研究发现BAZ1A作为染色质重塑复合物ACF1的关键亚基，通过其溴结构域特异性识别组蛋白H3K14乙酰化(H3K14ac)，调控染色质开放状态，影响DNA复制和修复过程。
2. **文献名称**：*"BAZ1A haploinsufficiency linked to neurodevelopmental defects in Williams syndrome"*
**作者**：Dillon, S.C. et al. (2015)
**摘要**：通过基因组关联分析，提出BAZ1A的单倍剂量不足可能参与威廉斯综合征(Williams syndrome)的神经发育异常，其机制可能与BAZ1A对神经元迁移相关基因的表观遗传调控有关。
3. **文献名称**：*"BAZ1A interacts with ATR kinase to stabilize replication forks under stress"*
**作者**：Liang, J. et al. (2018)
**摘要**：揭示BAZ1A在DNA复制应激中通过招募ATR激酶至停滞的复制叉，维持基因组稳定性，其锌指结构域在此过程中发挥关键作用。
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**注**：以上文献信息为综合领域知识模拟生成，具体文献需通过PubMed、Google Scholar等平台以“BAZ1A”、“ACF1 bromodomain”或“Williams syndrome BAZ1A”等关键词检索真实数据。
BAZ1A (Bromodomain Adjacent to Zinc Finger Domain 1A), also known as ACF1 or WSTF (Williams syndrome transcription factor), is a chromatin-remodeling protein encoded by the BAZ1A gene in humans. It belongs to the BAZ protein family, characterized by the presence of bromodomains and zinc finger motifs. BAZ1A serves as an essential regulatory subunit in ATP-dependent chromatin remodeling complexes, notably the ISWI (imitation switch) family complexes, including ACF (ATP-utilizing chromatin assembly and remodeling factor) and WICH (WSTF-ISWI chromatin remodeling complex). These complexes facilitate nucleosome positioning, chromatin condensation, and DNA replication/repair by coordinating histone modifications and ATPase-driven chromatin structural changes.
Structurally, BAZ1A contains multiple domains: a bromodomain that recognizes acetylated lysine residues on histones (linking it to epigenetic regulation), a WAC domain for protein-protein interactions, and a WSTF homology region involved in binding ISWI ATPases. Functionally, BAZ1A plays critical roles in transcriptional regulation, cell cycle progression, and genomic stability. It is implicated in developmental processes, particularly neurodevelopment, as mutations in BAZ1A-associated pathways are linked to Williams syndrome, a neurodevelopmental disorder. Additionally, BAZ1A's dysregulation has been associated with cancer progression due to its influence on chromatin dynamics and oncogene expression. Studies in model organisms, such as BAZ1A knockout mice, reveal embryonic lethality or developmental defects, underscoring its importance in cellular and organismal homeostasis. Ongoing research focuses on its therapeutic potential in chromatin-related diseases.
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