| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BAZ2A |
| Uniprot No | Q9UIF9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1905aa |
| 氨基酸序列 | MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLEPFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQEDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL |
| 分子量 | 211 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于BAZ2A的3篇代表性文献及其摘要内容的简要整理：
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1. **文献名称**：*BAZ2A is an epigenetic regulator of transcriptional elongation in prostate cancer*
**作者**：Chen et al. (2021)
**摘要**：研究发现BAZ2A作为染色质重塑复合物的核心组分，通过其溴结构域识别组蛋白乙酰化修饰，调控雄激素受体(AR)靶基因的转录延伸，促进前列腺癌细胞增殖及去势抵抗性前列腺癌进展。
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2. **文献名称**：*The role of BAZ2A in rRNA gene regulation and cellular senescence*
**作者**：Bachar et al. (2018)
**摘要**：该文献揭示BAZ2A通过结合核糖体RNA基因(rDNA)启动子区，招募组蛋白去乙酰化酶复合物，抑制rRNA转录，进而调控细胞衰老过程。敲低BAZ2A可延缓衰老相关表型。
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3. **文献名称**：*Structural basis of BAZ2A bromodomain interaction with acetylated histones*
**作者**：Guzzanti et al. (2020)
**摘要**：通过晶体结构解析，阐明BAZ2A的溴结构域与乙酰化组蛋白H3K14ac和H4K8ac的特异性结合机制，为开发靶向BAZ2A的小分子抑制剂提供结构基础。
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如需扩展其他研究领域(如BAZ2A与肥胖或神经退行性疾病)，可进一步补充。
BAZ2A (Bromodomain Adjacent to Zinc Finger Domain 2A), also known as TIP5 (TTF-I-interacting protein 5), is a chromatin-associated protein belonging to the BAZ protein family. It plays a critical role in chromatin remodeling and epigenetic regulation. Structurally, BAZ2A contains a bromodomain, which recognizes acetylated lysine residues on histones, and tandem plant homeodomain (PHD) fingers that mediate interactions with non-acetylated histone regions. It also features a nucleolar localization signal, linking it to ribosomal RNA (rRNA) gene regulation.
BAZ2A is a core component of the nucleolar remodeling complex (NoRC), essential for silencing rRNA genes by establishing heterochromatin. This process involves DNA methylation and histone modification, ensuring ribosomal DNA (rDNA) stability and suppressing aberrant recombination. Beyond nucleolar functions, BAZ2A regulates gene expression in non-ribosomal loci, influencing cellular differentiation and senescence. Notably, its dysregulation is implicated in cancers, where overexpression correlates with poor prognosis and metastasis. Recent studies highlight its emerging role in age-related diseases, including neurodegeneration, where abnormal BAZ2A expression disrupts neuronal homeostasis.
As a bromodomain-containing protein, BAZ2A is a potential therapeutic target, with ongoing research exploring inhibitors to modulate its chromatin-remodeling activity. Its dual role in nucleolar organization and genome-wide epigenetic regulation underscores its significance in both basic biology and disease mechanisms.
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