关键信息
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基因名
EphB3
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简介
The EphB3 protein is a receptor tyrosine kinase that performs bidirectional signaling with the transmembrane ephrin B ligand. It participates in forward signaling and reverse signaling, sharing functionality with EPHB2. EphB3 Protein, Human (sf9) is the recombinant human-derived EphB3, expressed by Sf9 insect cells , with tag Free labeled tag.
- 应用
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别名
EPHB3; EPH receptor B3; EK2; ETK2; HEK2; TYRO6
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P54753
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表达区间
K596-V998
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
EphB3 is a member of the Eph receptor tyrosine kinase family, which plays crucial roles in various cellular processes, including cell adhesion, migration, and differentiation. These receptors are primarily involved in the neural and vascular systems, influencing developmental processes and tissue organization. Dysregulation of EphB3 signaling has been implicated in several pathological conditions, including cancer, where it has been associated with tumor progression and metastasis. The study of EphB3 recombinant proteins is vital for understanding the structural and functional mechanisms underlying its activity. Researchers utilize recombinant protein techniques to produce EphB3 in a controlled environment, allowing for detailed analysis of its signaling pathways and interactions with ligands, particularly ephrins. This has significant implications for therapeutic applications, as targeted modulation of EphB3 signaling may provide novel strategies for cancer treatment and regenerative medicine. By generating EphB3 recombinant proteins, scientists can investigate its role in cellular contexts and explore potential interventions that could mitigate the effects of its dysregulation in disease states. Consequently, the ongoing research on EphB3 recombinant proteins not only expands our understanding of Eph receptor biology but also paves the way for innovative approaches to tackle various diseases linked to its aberrant functions.
