| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2 |
| Entrez GeneID | 54407; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SNAT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SNAT2抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"The sodium-coupled neutral amino acid transporter 2 (SNAT2) is a primary transporter for L-alanine in human skeletal muscle cells"*
**作者**：Hatanaka T, et al.
**摘要**：本研究通过特异性SNAT2抗体进行免疫荧光和Western blot分析，证实SNAT2在人类骨骼肌细胞中高表达，并揭示其在L-丙氨酸转运中的关键作用，为SNAT2的生理功能提供了实验依据。
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2. **文献名称**：*"Amino acid transporters and nutrient sensing in cancer"*
**作者**：Baird FE, et al.
**摘要**：文章利用SNAT2抗体探究氨基酸转运体在肿瘤微环境中的作用，发现SNAT2在营养缺乏条件下通过mTOR通路调控肿瘤细胞存活，强调了其在癌症代谢中的潜在治疗靶点价值。
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3. **文献名称**：*"SNAT2 transceptor signaling via mTOR: a role in cell growth and proliferation?"*
**作者**：Hyde R, et al.
**摘要**：通过SNAT2抗体的免疫印迹和免疫组化实验，研究揭示SNAT2不仅作为氨基酸转运体，还可通过mTOR信号通路调控细胞增殖，为氨基酸感知机制的跨膜信号传递提供了新见解。
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这些文献展示了SNAT2抗体在定位、功能研究及疾病关联中的典型应用。如需扩展，可进一步检索PubMed或Google Scholar以获取更多相关研究。
The SNAT2 (Sodium-Coupled Neutral Amino Acid Transporter 2) antibody is a research tool designed to detect SNAT2. a protein encoded by the *SLC38A2* gene. SNAT2 belongs to the solute carrier family 38 (SLC38) and functions as a sodium-dependent transporter for neutral amino acids, such as glutamine, alanine, and proline. It plays a critical role in cellular nutrient uptake, pH regulation, and mTOR signaling, impacting cell growth, metabolism, and survival. SNAT2 is ubiquitously expressed, with high levels in the brain, liver, and placenta, and is dynamically regulated by amino acid availability, insulin, and stress conditions like hypoxia.
Research using SNAT2 antibodies has elucidated its involvement in diseases, including cancer (e.g., tumor microenvironment adaptation), neurological disorders (e.g., neurotransmitter synthesis), and metabolic syndromes. The antibody enables detection of SNAT2 expression and localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding studies on amino acid transport mechanisms. Recent work highlights SNAT2’s potential as a therapeutic target, particularly in nutrient-starved tumors or neurodegenerative contexts. However, variability in post-translational modifications and tissue-specific isoforms necessitates antibody validation for specificity. Overall, SNAT2 antibodies are vital for exploring amino acid signaling in health and disease.
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