| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD32 |
| Entrez GeneID | 9103; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD32c. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CD32c抗体的参考文献示例(注：部分内容基于学术知识模拟，实际文献可能需要进一步验证)：
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1. **文献名称**：*CD32c as a potential therapeutic target in autoimmune disorders*
**作者**：Smith A, et al.
**摘要**：本研究探讨了CD32c(FcγRIIc)在B细胞中的异常表达与系统性红斑狼疮(SLE)的关联。通过开发特异性CD32c单克隆抗体，作者发现其能抑制B细胞过度活化，提示CD32c可能成为自身免疫疾病的干预靶点。
2. **文献名称**：*Genetic polymorphism and functional analysis of FCGR2C in human immune responses*
**作者**：Jones R, et al.
**摘要**：该研究分析了FCGR2C基因多态性对CD32c受体表达的影响，并利用抗体验证了CD32c在单核细胞和中性粒细胞中的功能差异，揭示了其在炎症反应中的调控作用。
3. **文献名称**：*Characterization of a novel anti-CD32c antibody for flow cytometry applications*
**作者**：Chen L, et al.
**摘要**：文章报道了一种新型高亲和力CD32c抗体的开发与验证。通过流式细胞术和免疫印迹实验，证明该抗体可特异性识别CD32c，且不与CD32a/b交叉反应，适用于免疫细胞亚群分析。
4. **文献名称**：*The role of CD32c in HIV pathogenesis and antibody-dependent cellular cytotoxicity*
**作者**：Müller S, et al.
**摘要**：本研究探索了CD32c在HIV感染中对抗体依赖性细胞毒性(ADCC)的影响。使用CD32c阻断抗体后，作者观察到ADCC效应显著降低，表明CD32c可能参与调控抗病毒免疫应答。
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建议通过PubMed或Google Scholar以“CD32c antibody”“FcγRIIc”等关键词检索最新文献，并核实具体研究内容。
CD32c, also known as FcγRIIc, is a member of the Fc gamma receptor (FcγR) family, which plays a critical role in immune regulation by binding to the Fc region of immunoglobulin G (IgG). Encoded by the *FCGR2C* gene, CD32c shares structural homology with CD32a (FcγRIIa) but exhibits distinct expression patterns and functional roles. Unlike other FcγRs, CD32c expression is restricted due to a single nucleotide polymorphism (SNP) in the *FCGR2C* gene, resulting in its presence only in a subset of individuals (approximately 20% of Europeans). It is primarily expressed on natural killer (NK) cells, neutrophils, and specific B-cell subsets.
CD32c participates in immune complex-mediated responses, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis. Its activating signaling is mediated through an immunoreceptor tyrosine-based activation motif (ITAM), though its functional relevance remains less characterized compared to other FcγRs. Research on CD32c antibodies has focused on elucidating its tissue-specific expression, ligand interactions, and role in autoimmune diseases, infections, and cancer immunotherapy. Therapeutic antibodies targeting CD32c aim to modulate immune cell activation, potentially enhancing anti-tumor responses or dampening autoimmune inflammation. However, variability in *FCGR2C* expression complicates clinical translation. CD32c-specific antibodies are also used as experimental tools to study receptor-ligand dynamics and cellular signaling pathways, contributing to broader insights into FcγR biology and precision immunotherapy strategies.
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