| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/ 50-200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ZNF481; bioref |
| Entrez GeneID | 57684; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ZBTB26 ? |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZBTB26抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: "ZBTB26 is a novel tumor suppressor in acute myeloid leukemia"
**作者**: Smith J, et al.
**摘要**: 本研究利用ZBTB26特异性抗体通过免疫印迹和免疫组化分析，发现ZBTB26在急性髓系白血病(AML)患者中表达显著下调，其缺失与不良预后相关，提示其作为肿瘤抑制因子的潜在作用。
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2. **文献名称**: "Characterization of a monoclonal antibody against ZBTB26 for epigenetic studies"
**作者**: Lee H, et al.
**摘要**: 文章报道了一种高特异性抗ZBTB26单克隆抗体的开发与验证，通过染色质免疫沉淀(ChIP)和免疫荧光实验，证实该抗体可用于研究ZBTB26在表观遗传调控及DNA损伤应答中的分子机制。
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3. **文献名称**: "ZBTB26 mutations and antibody-based detection in lymphoid malignancies"
**作者**: Gonzalez M, et al.
**摘要**: 研究者使用ZBTB26抗体对淋巴瘤组织样本进行免疫组化分析，发现ZBTB26基因突变导致蛋白表达异常，并与B细胞恶性肿瘤的病理进展相关，为诊断标志物开发提供了依据。
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注：以上文献为示例，实际引用时需根据具体研究核实标题、作者及内容。建议通过PubMed或Google Scholar以“ZBTB26 antibody”为关键词检索最新文献。
The ZBTB26 antibody is a research tool designed to detect and study the zinc finger and BTB domain-containing protein 26 (ZBTB26), a transcription factor encoded by the ZBTB26 gene in humans. This protein belongs to the BTB/POZ-ZF family, characterized by an N-terminal BTB/POZ domain for protein-protein interactions and C-terminal zinc finger motifs for DNA binding. ZBTB26 is implicated in transcriptional regulation, though its precise biological roles remain less characterized compared to other family members like BCL6 or ZBTB7A.
Antibodies targeting ZBTB26 are typically developed in rabbits or mice using immunogenic peptides or recombinant protein fragments. They are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate ZBTB26's expression patterns, subcellular localization, and interactions with DNA or other proteins.
Emerging studies suggest ZBTB26 may play roles in immune regulation, hematopoiesis, and cancer. For example, aberrant ZBTB26 expression has been observed in certain lymphomas and leukemias, hinting at potential involvement in oncogenesis or tumor suppression. However, functional data are limited, and research using ZBTB26 antibodies aims to clarify its molecular mechanisms, tissue-specific functions, and relevance to disease pathways. Commercial availability of these antibodies through suppliers like Abcam or Santa Cruz Biotechnology facilitates ongoing exploration of ZBTB26's contributions to cellular processes and pathologies.
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