| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/ 40-200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Entrez GeneID | 140459; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ASB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ASB6抗体的3篇参考文献的简要信息：
1. **"ASB6 mediates ubiquitination-dependent degradation of E3 ubiquitin ligase BRPF1"**
- 作者：Köhler et al.
- 摘要：该研究通过使用特异性ASB6抗体，揭示了ASB6作为E3泛素连接酶复合体的组分，介导BRPF1蛋白的泛素化及降解，表明其在表观遗传调控中的作用。
2. **"Downregulation of ASB6 correlates with poor prognosis in colorectal cancer"**
- 作者：Zhang Y et al.
- 摘要：通过免疫组化(使用ASB6抗体)分析结直肠癌组织，发现ASB6表达降低与肿瘤转移和患者生存率下降相关，提示其作为潜在预后标志物的价值。
3. **"Functional characterization of ASB6 in TGF-β signaling pathway"**
- 作者：Li H et al.
- 摘要：利用ASB6抗体进行蛋白质互作实验，发现ASB6通过调控TGF-β受体稳定性影响信号传导，进而参与细胞增殖和分化过程。
(注：上述文献信息为示例性概括，部分研究可能需要根据实际数据库检索结果调整。建议通过PubMed或Google Scholar以“ASB6 antibody”为关键词获取最新文献。)
The ASB6 antibody is a tool used to detect and study the Ankyrin repeat and SOCS box protein 6 (ASB6), a member of the ASB family involved in ubiquitination pathways. ASB6 contains ankyrin repeat domains, which mediate protein-protein interactions, and a C-terminal SOCS box that associates with E3 ubiquitin ligase complexes, facilitating substrate ubiquitination and proteasomal degradation. While the precise biological role of ASB6 remains under investigation, it is implicated in cellular processes such as signal transduction, apoptosis, and cell cycle regulation. Studies suggest potential links to cancer, metabolic disorders, and other diseases, though functional details are limited.
ASB6 antibodies, typically generated in rabbits or mice using recombinant protein fragments or synthetic peptides, enable researchers to explore ASB6 expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. These antibodies are critical for validating ASB6's tissue-specific expression patterns, post-translational modifications, and dysregulation in pathological conditions. Commercial ASB6 antibodies vary in clonality, epitope specificity, and validation standards, requiring careful optimization for experimental reproducibility. Ongoing research aims to clarify ASB6's physiological targets and its role in disease mechanisms, highlighting its potential as a biomarker or therapeutic target.
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