Rabbit Polyclonal NKD2 Antibody

The NKD2 (Naked Cuticle Homolog 2) antibody is a tool used to study the NKD2 protein, a key regulator of the Wnt/β-catenin signaling pathway. NKD2 functions as a feedback inhibitor of Wnt signaling by binding to Dishevelled (Dvl) proteins, thereby destabilizing β-catenin and suppressing target gene expression. It plays critical roles in embryonic development, tissue homeostasis, and cell differentiation. Dysregulation of NKD2 is implicated in various cancers, where it may act as either a tumor suppressor or promoter depending on context. For instance, reduced NKD2 expression has been observed in colorectal and gastric cancers, correlating with poor prognosis, while overexpression is linked to breast cancer progression. The NKD2 antibody enables detection and quantification of NKD2 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore NKD2's spatial-temporal expression patterns, interactions with signaling components, and therapeutic potential. Its applications extend to studying Wnt-driven pathologies, including cancer metastasis, fibrosis, and developmental disorders. Commercial NKD2 antibodies are typically raised against specific epitopes, with validation in knockout controls ensuring specificity. Ongoing research aims to clarify NKD2's dual roles in different cancers and its utility as a diagnostic marker or therapeutic target.